Choroidal neovascularization in unilateral acute idiopathic maculopathy associated with coxsackievirus B2

The purpose of the study was to present a case of choroidal neovascularization (CNV) in unilateral acute idiopathic maculopathy (UAIM) associated with coxsackievirus B2. We present a case of UAIM with coxsackie B2 positive serology, presenting CNV as a complication. Follow-up multimodal retinal imaging was performed to characterize the macular abnormalities further. A 27-year-old woman complained of a sudden central visual field scotoma in her left eye (LE) 2 days before her presentation. The patient reported flu-like symptoms 2 weeks before her initial ophthalmic symptoms. Ophthalmologic examination and multimodal imaging were performed at the initial presentation and 2 months follow-up when CNV was detected. The patient underwent an intravitreous ranibizumab injection in the LE. After the injection, the optical coherence tomography was repeated and there was a partial decrement of the subretinal hyperreflective area, and visual acuity improved to 20/30. To the best of our knowledge, no previous reports were found linking coxsackie B2 infection with UAIM and CNV. The present case report demonstrates the importance of serial multimodal imaging to guarantee accurate diagnosis and effective therapy for patients with UAIM secondary to coxsackievirus infection, regardless of the virus variant involved.