Choroid plexus volume differentiates MS from its mimics

Elle Levit; Zheng Ren; Virgilio Gonzenbach; Christina J. Azevedo; Peter A. Calabresi; Bruce A.C. Cree; Leorah Freeman; Erin E. Longbrake; Jiwon Oh; Matthew K. Schindler; Nancy L. Sicotte; Daniel Salo Reich; Daniel Ontaneda; Pascal Sati; Quy Cao; Russell T. Shinohara; Andrew J. Solomon

doi:10.1177/13524585241238094

Choroid plexus volume differentiates MS from its mimics

Elle Levit, Zheng Ren, Virgilio Gonzenbach, Christina J. Azevedo, Peter A. Calabresi, Bruce A.C. Cree, Leorah Freeman, Erin E. Longbrake, Jiwon Oh, Matthew K. Schindler, Nancy L. Sicotte, Daniel Salo Reich, Daniel Ontaneda, Pascal Sati, Quy Cao, Russell T. Shinohara, Andrew J. Solomon

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

This study aimed to determine whether choroid plexus volume (CPV) could differentiate multiple sclerosis (MS) from its mimics. A secondary analysis of two previously enrolled studies, 50 participants with MS and 64 with alternative diagnoses were included. CPV was automatically segmented from 3T magnetic resonance imaging (MRI), followed by manual review to remove misclassified tissue. Mean normalized choroid plexus volume (nCPV) to intracranial volume demonstrated relatively high specificity for MS participants in each cohort (0.80 and 0.76) with an area under the receiver-operator characteristic curve of 0.71 (95% confidence interval (CI) = 0.55–0.87) and 0.65 (95% CI = 0.52–0.77). In this preliminary study, nCPV differentiated MS from its mimics.

Original language	English (US)
Pages (from-to)	1072-1076
Number of pages	5
Journal	Multiple Sclerosis Journal
Volume	30
Issue number	8
DOIs	https://doi.org/10.1177/13524585241238094
State	Published - Jul 2024

Keywords

MRI
Multiple sclerosis
biomarker
diagnosis
differential diagnosis
misdiagnosis

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1177/13524585241238094

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Levit, E., Ren, Z., Gonzenbach, V., Azevedo, C. J., Calabresi, P. A., Cree, B. A. C., Freeman, L., Longbrake, E. E., Oh, J., Schindler, M. K., Sicotte, N. L., Reich, D. S., Ontaneda, D., Sati, P., Cao, Q., Shinohara, R. T., & Solomon, A. J. (2024). Choroid plexus volume differentiates MS from its mimics. Multiple Sclerosis Journal, 30(8), 1072-1076. https://doi.org/10.1177/13524585241238094

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title = "Choroid plexus volume differentiates MS from its mimics",

abstract = "This study aimed to determine whether choroid plexus volume (CPV) could differentiate multiple sclerosis (MS) from its mimics. A secondary analysis of two previously enrolled studies, 50 participants with MS and 64 with alternative diagnoses were included. CPV was automatically segmented from 3T magnetic resonance imaging (MRI), followed by manual review to remove misclassified tissue. Mean normalized choroid plexus volume (nCPV) to intracranial volume demonstrated relatively high specificity for MS participants in each cohort (0.80 and 0.76) with an area under the receiver-operator characteristic curve of 0.71 (95% confidence interval (CI) = 0.55–0.87) and 0.65 (95% CI = 0.52–0.77). In this preliminary study, nCPV differentiated MS from its mimics.",

keywords = "MRI, Multiple sclerosis, biomarker, diagnosis, differential diagnosis, misdiagnosis",

author = "Elle Levit and Zheng Ren and Virgilio Gonzenbach and Azevedo, {Christina J.} and Calabresi, {Peter A.} and Cree, {Bruce A.C.} and Leorah Freeman and Longbrake, {Erin E.} and Jiwon Oh and Schindler, {Matthew K.} and Sicotte, {Nancy L.} and Reich, {Daniel Salo} and Daniel Ontaneda and Pascal Sati and Quy Cao and Shinohara, {Russell T.} and Solomon, {Andrew J.}",

note = "Publisher Copyright: {\textcopyright} The Author(s), 2024.",

year = "2024",

month = jul,

doi = "10.1177/13524585241238094",

language = "English (US)",

volume = "30",

pages = "1072--1076",

journal = "Multiple Sclerosis Journal",

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T1 - Choroid plexus volume differentiates MS from its mimics

AU - Levit, Elle

AU - Ren, Zheng

AU - Gonzenbach, Virgilio

AU - Azevedo, Christina J.

AU - Calabresi, Peter A.

AU - Cree, Bruce A.C.

AU - Freeman, Leorah

AU - Longbrake, Erin E.

AU - Oh, Jiwon

AU - Schindler, Matthew K.

AU - Sicotte, Nancy L.

AU - Reich, Daniel Salo

AU - Ontaneda, Daniel

AU - Sati, Pascal

AU - Cao, Quy

AU - Shinohara, Russell T.

AU - Solomon, Andrew J.

N1 - Publisher Copyright: © The Author(s), 2024.

PY - 2024/7

Y1 - 2024/7

N2 - This study aimed to determine whether choroid plexus volume (CPV) could differentiate multiple sclerosis (MS) from its mimics. A secondary analysis of two previously enrolled studies, 50 participants with MS and 64 with alternative diagnoses were included. CPV was automatically segmented from 3T magnetic resonance imaging (MRI), followed by manual review to remove misclassified tissue. Mean normalized choroid plexus volume (nCPV) to intracranial volume demonstrated relatively high specificity for MS participants in each cohort (0.80 and 0.76) with an area under the receiver-operator characteristic curve of 0.71 (95% confidence interval (CI) = 0.55–0.87) and 0.65 (95% CI = 0.52–0.77). In this preliminary study, nCPV differentiated MS from its mimics.

AB - This study aimed to determine whether choroid plexus volume (CPV) could differentiate multiple sclerosis (MS) from its mimics. A secondary analysis of two previously enrolled studies, 50 participants with MS and 64 with alternative diagnoses were included. CPV was automatically segmented from 3T magnetic resonance imaging (MRI), followed by manual review to remove misclassified tissue. Mean normalized choroid plexus volume (nCPV) to intracranial volume demonstrated relatively high specificity for MS participants in each cohort (0.80 and 0.76) with an area under the receiver-operator characteristic curve of 0.71 (95% confidence interval (CI) = 0.55–0.87) and 0.65 (95% CI = 0.52–0.77). In this preliminary study, nCPV differentiated MS from its mimics.

KW - MRI

KW - Multiple sclerosis

KW - biomarker

KW - diagnosis

KW - differential diagnosis

KW - misdiagnosis

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Choroid plexus volume differentiates MS from its mimics

Abstract

Keywords

ASJC Scopus subject areas

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