TY - JOUR
T1 - Cholinergic Mechanisms in Affective Disorders
AU - Snyder, Solomon H.
PY - 1984/7/26
Y1 - 1984/7/26
N2 - Strong evidence of a genetic vulnerability for the development of major forms of affective disorder suggests that manic and depressive symptoms are caused by specific biochemical abnormalities. Clues for particular chemical lesions have come mostly from the known effects of mood-altering drugs on neurotransmitters. Much current thinking favors a biogenicamine hypothesis, based on findings that antidepressant drugs all facilitate the synaptic activities of amines such as norepinephrine and serotonin, whether by inhibiting their neuronal-uptake inactivation, preventing their metabolic degradation, or other means. In a substantial number of patients, reserpine, which depletes the brain of its amine content, elicits a depressive.
AB - Strong evidence of a genetic vulnerability for the development of major forms of affective disorder suggests that manic and depressive symptoms are caused by specific biochemical abnormalities. Clues for particular chemical lesions have come mostly from the known effects of mood-altering drugs on neurotransmitters. Much current thinking favors a biogenicamine hypothesis, based on findings that antidepressant drugs all facilitate the synaptic activities of amines such as norepinephrine and serotonin, whether by inhibiting their neuronal-uptake inactivation, preventing their metabolic degradation, or other means. In a substantial number of patients, reserpine, which depletes the brain of its amine content, elicits a depressive.
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U2 - 10.1056/NEJM198407263110410
DO - 10.1056/NEJM198407263110410
M3 - Editorial
C2 - 6738620
AN - SCOPUS:0021201240
SN - 0028-4793
VL - 311
SP - 254
EP - 255
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 4
ER -