Choline: High-affinity uptake by rat brain synaptosomes

Henry I. Yamamura, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

224 Scopus citations


Synaptosomes from rat brain accumulate choline by two kinetically distinct processes, a high-affinity uptake system [Michaelis constant (Km) = 1 X 10-6M], and a low-affinity system (Km = 9 X 10 -5M). The high-affinity uptake system requires sodium, and is associated with considerable formation of acetylcholine. The low-affinity uptake system is less dependent on sodium, and does not appear to be associated with a marked degree of acetylcholine formation. The high-affinity choline uptake appears to represent selective choline accumulation by cholinergic neurons.

Original languageEnglish (US)
Pages (from-to)626-628
Number of pages3
Issue number4061
StatePublished - Jan 1 1972

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Choline: High-affinity uptake by rat brain synaptosomes'. Together they form a unique fingerprint.

Cite this