Choices of stimulation for low responders in IVF

Ziad R. Hubayter, Suheil J. Muasher

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Low responders present a significant challenge for IVF practitioners due to the lower chances of a pregnancy in relation to the usual high cost of treatment. The definition of low responders is not universally agreed upon and the literature is full of articles that have different populations of low responders, which makes comparisons of the different protocols almost impossible. This paper will review the different strategies and protocols that have been reported and discuss the advantages and disadvantages of each. It is of utmost importance to realize that, at the present time, there is no regimen of ovarian stimulation that can change a true low responder into a high responder. Minimal stimulation and natural cycle protocols for IVF appear to be reasonable choices in well-selected cases since they provide simplicity and cost-effectiveness.

Original languageEnglish (US)
Pages (from-to)531-538
Number of pages8
JournalExpert Review of Obstetrics and Gynecology
Issue number4
StatePublished - Jul 2008
Externally publishedYes


  • Assisted reproductive technology
  • Clomiphene citrate
  • GnRH agonist
  • GnRH antagonist
  • Growth hormone
  • IVF
  • Low responders
  • Minimal stimulation
  • Natural cycle

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Maternity and Midwifery


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