TY - JOUR
T1 - Childhood Serum Anti-Fetal Brain Antibodies Do Not Predict Autism
AU - Morris, Christina M.
AU - Zimmerman, Andrew W.
AU - Singer, Harvey S.
N1 - Funding Information:
The authors thank Shilpa Vernekar, MD, and Colin Gause, MS, for their assistance in the laboratory. Human fetal brain tissue was provided by the National Institute of Child Health and Human Development (NIH-NICHD) Brain and Tissue Bank for Developmental Disorders at the University of Maryland, Baltimore, MD. This work was supported in part by the Hussman Foundation.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2009/10
Y1 - 2009/10
N2 - Autoimmune hypotheses for autism include in utero transplacental exposure to maternal antibodies and acquired postnatal insults. Previous work demonstrated that some mothers of children with autistic disorder have specific antibodies against human fetal brain that differentiate them from mothers with typical children. In the present study, Western immunoblotting was used to determine whether children with autistic spectrum disorders (n = 29) have serum reactivity against human fetal brain that differs from that of controls (n = 14). There was no significant difference in reactivity, corrected for serum immunoglobulin G content and brain actin content and with special attention to reactive bands at 36, 39, 61, and 73 kDa, between autistic children and normal control subjects. Thus, in contrast to mothers, antibody reactivity against human fetal brain as measured in children ages 3-12 years does not appear to be a useful biomarker for autism.
AB - Autoimmune hypotheses for autism include in utero transplacental exposure to maternal antibodies and acquired postnatal insults. Previous work demonstrated that some mothers of children with autistic disorder have specific antibodies against human fetal brain that differentiate them from mothers with typical children. In the present study, Western immunoblotting was used to determine whether children with autistic spectrum disorders (n = 29) have serum reactivity against human fetal brain that differs from that of controls (n = 14). There was no significant difference in reactivity, corrected for serum immunoglobulin G content and brain actin content and with special attention to reactive bands at 36, 39, 61, and 73 kDa, between autistic children and normal control subjects. Thus, in contrast to mothers, antibody reactivity against human fetal brain as measured in children ages 3-12 years does not appear to be a useful biomarker for autism.
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U2 - 10.1016/j.pediatrneurol.2009.04.014
DO - 10.1016/j.pediatrneurol.2009.04.014
M3 - Article
C2 - 19748049
AN - SCOPUS:69849086849
SN - 0887-8994
VL - 41
SP - 288
EP - 290
JO - Pediatric Neurology
JF - Pediatric Neurology
IS - 4
ER -