Childhood-onset schizophrenia: Smooth pursuit eye-tracking dysfunction in family members

Alexandra Sporn, Deanna Greenstein, Nitin Gogtay, Franziska Sailer, Daniel W. Hommer, Robert Rawlings, Rob Nicolson, Michael F. Egan, Marge Lenane, Peter Gochman, Daniel R. Weinberger, Judith L. Rapoport

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Childhood-onset schizophrenia (COS), a severe form of the disorder, is of interest for etiologic studies. Smooth pursuit eye-tracking dysfunction (ETD) is a biological marker for schizophrenia. To compare familial eye-tracking abnormalities for COS and adult-onset schizophrenia (AOS). Eye-tracking performance for 70 COS parents, 64 AOS parents and 20 COS siblings was compared to their respective age-matched control groups. COS and AOS parents had higher rate of dichotomously rated eye-tracking dysfunction than their respective controls (16% vs. 1% and 22% vs. 4%, respectively). COS parents and siblings also differed from controls on several continuous measures. However, scores for COS, AOS and control groups overlapped extensively. Genetic factors underlying eye-tracking dysfunction appear more salient for COS. However, eye-tracking measures have to be used with caution for endophenotypic definition due to low predictive power. The study was done at the National Institutes of Health.

Original languageEnglish (US)
Pages (from-to)243-252
Number of pages10
JournalSchizophrenia Research
Issue number2-3
StatePublished - Mar 1 2005
Externally publishedYes


  • AOS
  • COS
  • Smooth pursuit eye-tracking dysfunction

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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