TY - JOUR
T1 - Childhood-onset schizophrenia
T2 - Smooth pursuit eye-tracking dysfunction in family members
AU - Sporn, Alexandra
AU - Greenstein, Deanna
AU - Gogtay, Nitin
AU - Sailer, Franziska
AU - Hommer, Daniel W.
AU - Rawlings, Robert
AU - Nicolson, Rob
AU - Egan, Michael F.
AU - Lenane, Marge
AU - Gochman, Peter
AU - Weinberger, Daniel R.
AU - Rapoport, Judith L.
PY - 2005/3/1
Y1 - 2005/3/1
N2 - Childhood-onset schizophrenia (COS), a severe form of the disorder, is of interest for etiologic studies. Smooth pursuit eye-tracking dysfunction (ETD) is a biological marker for schizophrenia. To compare familial eye-tracking abnormalities for COS and adult-onset schizophrenia (AOS). Eye-tracking performance for 70 COS parents, 64 AOS parents and 20 COS siblings was compared to their respective age-matched control groups. COS and AOS parents had higher rate of dichotomously rated eye-tracking dysfunction than their respective controls (16% vs. 1% and 22% vs. 4%, respectively). COS parents and siblings also differed from controls on several continuous measures. However, scores for COS, AOS and control groups overlapped extensively. Genetic factors underlying eye-tracking dysfunction appear more salient for COS. However, eye-tracking measures have to be used with caution for endophenotypic definition due to low predictive power. The study was done at the National Institutes of Health.
AB - Childhood-onset schizophrenia (COS), a severe form of the disorder, is of interest for etiologic studies. Smooth pursuit eye-tracking dysfunction (ETD) is a biological marker for schizophrenia. To compare familial eye-tracking abnormalities for COS and adult-onset schizophrenia (AOS). Eye-tracking performance for 70 COS parents, 64 AOS parents and 20 COS siblings was compared to their respective age-matched control groups. COS and AOS parents had higher rate of dichotomously rated eye-tracking dysfunction than their respective controls (16% vs. 1% and 22% vs. 4%, respectively). COS parents and siblings also differed from controls on several continuous measures. However, scores for COS, AOS and control groups overlapped extensively. Genetic factors underlying eye-tracking dysfunction appear more salient for COS. However, eye-tracking measures have to be used with caution for endophenotypic definition due to low predictive power. The study was done at the National Institutes of Health.
KW - AOS
KW - COS
KW - Smooth pursuit eye-tracking dysfunction
UR - http://www.scopus.com/inward/record.url?scp=19944426341&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=19944426341&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2004.07.020
DO - 10.1016/j.schres.2004.07.020
M3 - Article
C2 - 15653267
AN - SCOPUS:19944426341
SN - 0920-9964
VL - 73
SP - 243
EP - 252
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 2-3
ER -