Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions

E. J. Fuchs; A. Seher; V. Altomonte; H. G. Braine; R. L. Humphrey; R. J. Jones; S. J. Noga; K. Schepers; S. K. Wright; G. B. Vogelsang

doi:10.1038/sj.bmt.1701323

Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions

E. J. Fuchs
, A. Seher
, V. Altomonte
, H. G. Braine
, R. L. Humphrey
, R. J. Jones
, S. J. Noga
, K. Schepers
, S. K. Wright
, G. B. Vogelsang

School of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Two patients with multiple myeloma in relapse after allogeneic BMT received donor lymphocyte infusions (DLI) but later required chemotherapy for treatment of myeloma-related complications. In both patients, recovery from chemotherapy-induced aplasia was accompanied by manifestations of graft-versus-host reactions. The first patient developed grade II acute GVHD and a complete remission which has lasted > 22 months. The second patient developed grade III acute GVHD but died with co-existing GVHD and extensive extramedullary myeloma. These results demonstrate that chemotherapy does not nullify the ability of donor lymphocytes to mediate graft-versus-host reactions.

Original language	English (US)
Pages (from-to)	303-305
Number of pages	3
Journal	Bone marrow transplantation
Volume	22
Issue number	3
DOIs	https://doi.org/10.1038/sj.bmt.1701323
State	Published - 1998

Keywords

Bone marrow transplantation
Chemotherapy
Graft-versus-host disease
Graft-versus-myeloma
Leukocyte transfusions
Multiple myeloma

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/sj.bmt.1701323

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@article{bc344e4b0b884e249385855c058b80b3,

title = "Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions",

abstract = "Two patients with multiple myeloma in relapse after allogeneic BMT received donor lymphocyte infusions (DLI) but later required chemotherapy for treatment of myeloma-related complications. In both patients, recovery from chemotherapy-induced aplasia was accompanied by manifestations of graft-versus-host reactions. The first patient developed grade II acute GVHD and a complete remission which has lasted > 22 months. The second patient developed grade III acute GVHD but died with co-existing GVHD and extensive extramedullary myeloma. These results demonstrate that chemotherapy does not nullify the ability of donor lymphocytes to mediate graft-versus-host reactions.",

keywords = "Bone marrow transplantation, Chemotherapy, Graft-versus-host disease, Graft-versus-myeloma, Leukocyte transfusions, Multiple myeloma",

author = "Fuchs, \{E. J.\} and A. Seher and V. Altomonte and Braine, \{H. G.\} and Humphrey, \{R. L.\} and Jones, \{R. J.\} and Noga, \{S. J.\} and K. Schepers and Wright, \{S. K.\} and Vogelsang, \{G. B.\}",

note = "Funding Information: This work was supported by grant P01 CA15396 from the National Cancer Institute. RJJ is a Scholar of the Leukemia Society of America.",

year = "1998",

doi = "10.1038/sj.bmt.1701323",

language = "English (US)",

volume = "22",

pages = "303--305",

journal = "Bone marrow transplantation",

issn = "0268-3369",

publisher = "Springer Nature",

number = "3",

}

TY - JOUR

T1 - Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions

AU - Fuchs, E. J.

AU - Seher, A.

AU - Altomonte, V.

AU - Braine, H. G.

AU - Humphrey, R. L.

AU - Jones, R. J.

AU - Noga, S. J.

AU - Schepers, K.

AU - Wright, S. K.

AU - Vogelsang, G. B.

N1 - Funding Information: This work was supported by grant P01 CA15396 from the National Cancer Institute. RJJ is a Scholar of the Leukemia Society of America.

PY - 1998

Y1 - 1998

N2 - Two patients with multiple myeloma in relapse after allogeneic BMT received donor lymphocyte infusions (DLI) but later required chemotherapy for treatment of myeloma-related complications. In both patients, recovery from chemotherapy-induced aplasia was accompanied by manifestations of graft-versus-host reactions. The first patient developed grade II acute GVHD and a complete remission which has lasted > 22 months. The second patient developed grade III acute GVHD but died with co-existing GVHD and extensive extramedullary myeloma. These results demonstrate that chemotherapy does not nullify the ability of donor lymphocytes to mediate graft-versus-host reactions.

AB - Two patients with multiple myeloma in relapse after allogeneic BMT received donor lymphocyte infusions (DLI) but later required chemotherapy for treatment of myeloma-related complications. In both patients, recovery from chemotherapy-induced aplasia was accompanied by manifestations of graft-versus-host reactions. The first patient developed grade II acute GVHD and a complete remission which has lasted > 22 months. The second patient developed grade III acute GVHD but died with co-existing GVHD and extensive extramedullary myeloma. These results demonstrate that chemotherapy does not nullify the ability of donor lymphocytes to mediate graft-versus-host reactions.

KW - Bone marrow transplantation

KW - Chemotherapy

KW - Graft-versus-host disease

KW - Graft-versus-myeloma

KW - Leukocyte transfusions

KW - Multiple myeloma

UR - https://www.scopus.com/pages/publications/17144454218

UR - https://www.scopus.com/pages/publications/17144454218#tab=citedBy

U2 - 10.1038/sj.bmt.1701323

DO - 10.1038/sj.bmt.1701323

M3 - Article

C2 - 9720749

AN - SCOPUS:17144454218

SN - 0268-3369

VL - 22

SP - 303

EP - 305

JO - Bone marrow transplantation

JF - Bone marrow transplantation

IS - 3

ER -

Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions

Abstract

Keywords

ASJC Scopus subject areas

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