Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions

E. J. Fuchs; A. Seher; V. Altomonte; H. G. Braine; R. L. Humphrey; R. J. Jones; S. J. Noga; K. Schepers; S. K. Wright; G. B. Vogelsang

doi:10.1038/sj.bmt.1701323

Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions

E. J. Fuchs, A. Seher, V. Altomonte, H. G. Braine, R. L. Humphrey, R. J. Jones, S. J. Noga, K. Schepers, S. K. Wright, G. B. Vogelsang

School of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Two patients with multiple myeloma in relapse after allogeneic BMT received donor lymphocyte infusions (DLI) but later required chemotherapy for treatment of myeloma-related complications. In both patients, recovery from chemotherapy-induced aplasia was accompanied by manifestations of graft-versus-host reactions. The first patient developed grade II acute GVHD and a complete remission which has lasted > 22 months. The second patient developed grade III acute GVHD but died with co-existing GVHD and extensive extramedullary myeloma. These results demonstrate that chemotherapy does not nullify the ability of donor lymphocytes to mediate graft-versus-host reactions.

Original language	English (US)
Pages (from-to)	303-305
Number of pages	3
Journal	Bone marrow transplantation
Volume	22
Issue number	3
DOIs	https://doi.org/10.1038/sj.bmt.1701323
State	Published - 1998

Keywords

Bone marrow transplantation
Chemotherapy
Graft-versus-host disease
Graft-versus-myeloma
Leukocyte transfusions
Multiple myeloma

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/sj.bmt.1701323

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title = "Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions",

abstract = "Two patients with multiple myeloma in relapse after allogeneic BMT received donor lymphocyte infusions (DLI) but later required chemotherapy for treatment of myeloma-related complications. In both patients, recovery from chemotherapy-induced aplasia was accompanied by manifestations of graft-versus-host reactions. The first patient developed grade II acute GVHD and a complete remission which has lasted > 22 months. The second patient developed grade III acute GVHD but died with co-existing GVHD and extensive extramedullary myeloma. These results demonstrate that chemotherapy does not nullify the ability of donor lymphocytes to mediate graft-versus-host reactions.",

keywords = "Bone marrow transplantation, Chemotherapy, Graft-versus-host disease, Graft-versus-myeloma, Leukocyte transfusions, Multiple myeloma",

author = "Fuchs, {E. J.} and A. Seher and V. Altomonte and Braine, {H. G.} and Humphrey, {R. L.} and Jones, {R. J.} and Noga, {S. J.} and K. Schepers and Wright, {S. K.} and Vogelsang, {G. B.}",

note = "Funding Information: This work was supported by grant P01 CA15396 from the National Cancer Institute. RJJ is a Scholar of the Leukemia Society of America.",

year = "1998",

doi = "10.1038/sj.bmt.1701323",

language = "English (US)",

volume = "22",

pages = "303--305",

journal = "Bone marrow transplantation",

issn = "0268-3369",

publisher = "Springer Nature",

number = "3",

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T1 - Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions

AU - Fuchs, E. J.

AU - Seher, A.

AU - Altomonte, V.

AU - Braine, H. G.

AU - Humphrey, R. L.

AU - Jones, R. J.

AU - Noga, S. J.

AU - Schepers, K.

AU - Wright, S. K.

AU - Vogelsang, G. B.

N1 - Funding Information: This work was supported by grant P01 CA15396 from the National Cancer Institute. RJJ is a Scholar of the Leukemia Society of America.

PY - 1998

Y1 - 1998

N2 - Two patients with multiple myeloma in relapse after allogeneic BMT received donor lymphocyte infusions (DLI) but later required chemotherapy for treatment of myeloma-related complications. In both patients, recovery from chemotherapy-induced aplasia was accompanied by manifestations of graft-versus-host reactions. The first patient developed grade II acute GVHD and a complete remission which has lasted > 22 months. The second patient developed grade III acute GVHD but died with co-existing GVHD and extensive extramedullary myeloma. These results demonstrate that chemotherapy does not nullify the ability of donor lymphocytes to mediate graft-versus-host reactions.

AB - Two patients with multiple myeloma in relapse after allogeneic BMT received donor lymphocyte infusions (DLI) but later required chemotherapy for treatment of myeloma-related complications. In both patients, recovery from chemotherapy-induced aplasia was accompanied by manifestations of graft-versus-host reactions. The first patient developed grade II acute GVHD and a complete remission which has lasted > 22 months. The second patient developed grade III acute GVHD but died with co-existing GVHD and extensive extramedullary myeloma. These results demonstrate that chemotherapy does not nullify the ability of donor lymphocytes to mediate graft-versus-host reactions.

KW - Bone marrow transplantation

KW - Chemotherapy

KW - Graft-versus-host disease

KW - Graft-versus-myeloma

KW - Leukocyte transfusions

KW - Multiple myeloma

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DO - 10.1038/sj.bmt.1701323

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AN - SCOPUS:17144454218

SN - 0268-3369

VL - 22

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JO - Bone marrow transplantation

JF - Bone marrow transplantation

IS - 3

ER -

Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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