Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement

Hyun S. Shin; Ralph Snyderman; Eileen Friedman; Alice Mellors; Manfred M. Mayer

doi:10.1126/science.162.3851.361

Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement

Hyun S. Shin, Ralph Snyderman, Eileen Friedman, Alice Mellors, Manfred M. Mayer

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The fifth component of guinea pig complement, with a sedimentation coefficient 7.8S, is cleaved by sensitized sheep erythrocytes treated with the first four components of complement into two fragments with sedimentation coefficients of 7.4S and 1.5S. The smaller fragment, with a molecular weight of about 15,000, possesses chemotactic activity for rabbit polymorphonuclear leukocytes, as well as anaphylatoxic activity for guinea pig ileum.

Original language	English (US)
Pages (from-to)	361-363
Number of pages	3
Journal	Science
Volume	162
Issue number	3851
DOIs	https://doi.org/10.1126/science.162.3851.361
State	Published - 1968

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title = "Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement",

abstract = "The fifth component of guinea pig complement, with a sedimentation coefficient 7.8S, is cleaved by sensitized sheep erythrocytes treated with the first four components of complement into two fragments with sedimentation coefficients of 7.4S and 1.5S. The smaller fragment, with a molecular weight of about 15,000, possesses chemotactic activity for rabbit polymorphonuclear leukocytes, as well as anaphylatoxic activity for guinea pig ileum.",

author = "Shin, {Hyun S.} and Ralph Snyderman and Eileen Friedman and Alice Mellors and Mayer, {Manfred M.}",

year = "1968",

doi = "10.1126/science.162.3851.361",

language = "English (US)",

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AU - Shin, Hyun S.

AU - Snyderman, Ralph

AU - Friedman, Eileen

AU - Mellors, Alice

AU - Mayer, Manfred M.

PY - 1968

Y1 - 1968

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AB - The fifth component of guinea pig complement, with a sedimentation coefficient 7.8S, is cleaved by sensitized sheep erythrocytes treated with the first four components of complement into two fragments with sedimentation coefficients of 7.4S and 1.5S. The smaller fragment, with a molecular weight of about 15,000, possesses chemotactic activity for rabbit polymorphonuclear leukocytes, as well as anaphylatoxic activity for guinea pig ileum.

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ER -

Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement

Abstract

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