TY - JOUR
T1 - Chemical synthesis and biological evaluation of 1d-1,2,4,5-InsP4 and its 3-fluorinated counterpart 1d-3-F-1,2,4,5-InsP4 - potent 1d-1,4,5-InsP3-like calcium mobilizing analogues
AU - Kozikowski, Alan P.
AU - Fauq, Abdul H.
AU - Wilcox, Robert A.
AU - Nahorski, Stefan R.
PY - 1995/6/22
Y1 - 1995/6/22
N2 - Syntheses of optically pure 1d-3-F-2,4,5-InsP3, 1d-3-F-1,2,4,5-InsP4, and 1d-1,2,4,5-InsP4 are reported starting from l-quebrachitol. The latter two compounds are shown to be nearly equipotent to 1d-1,4,5-InsP3 in both binding and calcium release experiments.
AB - Syntheses of optically pure 1d-3-F-2,4,5-InsP3, 1d-3-F-1,2,4,5-InsP4, and 1d-1,2,4,5-InsP4 are reported starting from l-quebrachitol. The latter two compounds are shown to be nearly equipotent to 1d-1,4,5-InsP3 in both binding and calcium release experiments.
UR - http://www.scopus.com/inward/record.url?scp=0029076591&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029076591&partnerID=8YFLogxK
U2 - 10.1016/0960-894X(95)00210-K
DO - 10.1016/0960-894X(95)00210-K
M3 - Article
AN - SCOPUS:0029076591
SN - 0960-894X
VL - 5
SP - 1295
EP - 1300
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 12
ER -