Chemical approaches to reversible protein phosphorylation

Philip A. Cole, Aliya D. Courtney, Kui Shen, Zhongsen Zhang, Yingfeng Qiao, Wei Lu, Daniel M. Williams

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Protein phosphorylation catalyzed by protein kinases plays a critical role in cellular signaling. Here we review several chemical approaches to understanding protein kinases and the consequences of protein phosphorylation. We discuss the design of bisubstrate analogue inhibitors based on a dissociative transition state, the development of reagents for cross-linking protein kinases with their substrates, the chemical rescue of mutant protein tyrosine kinases, and the application of expressed protein ligation to understanding protein phosphorylation.

Original languageEnglish (US)
Pages (from-to)444-452
Number of pages9
JournalAccounts of chemical research
Issue number6
StatePublished - Jun 1 2003

ASJC Scopus subject areas

  • Chemistry(all)


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