Characterization of two marker chromosomes in a patient with acute nonlymphocytic leukemia by two-color fluorescence in situ hybridization

Masafumi Taniwaki; Michael R. Speicher; Christoph Lengauer; Anna Jauch; Susanne Popp; Thomas Cremer

doi:10.1016/0165-4608(93)90175-L

Characterization of two marker chromosomes in a patient with acute nonlymphocytic leukemia by two-color fluorescence in situ hybridization

Masafumi Taniwaki
, Michael R. Speicher
, Christoph Lengauer
, Anna Jauch
, Susanne Popp
, Thomas Cremer

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A patient with acute nonlymphocytic leukemia (ANLL), M5b according to French-American-British (FAB) classification, showed monosomy 16, an extra 1p-, and a 21q+. These derivative chromosomes could not be defined by GTG-banding. For better characterization, we performed two-color fluorescence in situ hybridization (FISH) experiments applying DNA libraries from sorted human chromosomes, chromosome-specific repetitive probes, and a band-specific YAC-clone. With these FISH studies the karyotype could be characterized as 46,XY,+der(1)t(1;21)(p11;?),-16,der(21)t(16;21)(p11.1;q22).

Original language	English (US)
Pages (from-to)	99-102
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	70
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(93)90175-L
State	Published - Oct 15 1993
Externally published	Yes

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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title = "Characterization of two marker chromosomes in a patient with acute nonlymphocytic leukemia by two-color fluorescence in situ hybridization",

abstract = "A patient with acute nonlymphocytic leukemia (ANLL), M5b according to French-American-British (FAB) classification, showed monosomy 16, an extra 1p-, and a 21q+. These derivative chromosomes could not be defined by GTG-banding. For better characterization, we performed two-color fluorescence in situ hybridization (FISH) experiments applying DNA libraries from sorted human chromosomes, chromosome-specific repetitive probes, and a band-specific YAC-clone. With these FISH studies the karyotype could be characterized as 46,XY,+der(1)t(1;21)(p11;?),-16,der(21)t(16;21)(p11.1;q22).",

author = "Masafumi Taniwaki and Speicher, \{Michael R.\} and Christoph Lengauer and Anna Jauch and Susanne Popp and Thomas Cremer",

year = "1993",

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doi = "10.1016/0165-4608(93)90175-L",

language = "English (US)",

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T1 - Characterization of two marker chromosomes in a patient with acute nonlymphocytic leukemia by two-color fluorescence in situ hybridization

AU - Taniwaki, Masafumi

AU - Speicher, Michael R.

AU - Lengauer, Christoph

AU - Jauch, Anna

AU - Popp, Susanne

AU - Cremer, Thomas

PY - 1993/10/15

Y1 - 1993/10/15

N2 - A patient with acute nonlymphocytic leukemia (ANLL), M5b according to French-American-British (FAB) classification, showed monosomy 16, an extra 1p-, and a 21q+. These derivative chromosomes could not be defined by GTG-banding. For better characterization, we performed two-color fluorescence in situ hybridization (FISH) experiments applying DNA libraries from sorted human chromosomes, chromosome-specific repetitive probes, and a band-specific YAC-clone. With these FISH studies the karyotype could be characterized as 46,XY,+der(1)t(1;21)(p11;?),-16,der(21)t(16;21)(p11.1;q22).

AB - A patient with acute nonlymphocytic leukemia (ANLL), M5b according to French-American-British (FAB) classification, showed monosomy 16, an extra 1p-, and a 21q+. These derivative chromosomes could not be defined by GTG-banding. For better characterization, we performed two-color fluorescence in situ hybridization (FISH) experiments applying DNA libraries from sorted human chromosomes, chromosome-specific repetitive probes, and a band-specific YAC-clone. With these FISH studies the karyotype could be characterized as 46,XY,+der(1)t(1;21)(p11;?),-16,der(21)t(16;21)(p11.1;q22).

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M3 - Article

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IS - 2

ER -

Characterization of two marker chromosomes in a patient with acute nonlymphocytic leukemia by two-color fluorescence in situ hybridization

Abstract

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