Characterization of the yeast transcriptome

Victor E. Velculescu, Lin Zhang, Wei Zhou, Jacob Vogelstein, Munira A. Basrai, Douglas E. Bassett, Phil Hieter, Bert Vogelstein, Kenneth W. Kinzler

Research output: Contribution to journalArticlepeer-review

849 Scopus citations


We have analyzed the set of genes expressed from the yeast genome, herein called the transcriptome, using serial analysis of gene expression. Analysis of 60,633 transcripts revealed 4,665 genes, with expression levels ranging from 0.3 to over 200 transcripts per cell. Of these genes, 1981 had known functions, while 2684 were previously uncharacterized. The integration of positional information with gene expression data allowed for the generation of chromosomal expression maps identifying physical regions of transcriptional activity and identified genes that had not been predicted by sequence information alone. These studies provide insight into global patterns of gene expression in yeast and demonstrate the feasibility of genome-wide expression studies in eukaryotes.

Original languageEnglish (US)
Pages (from-to)243-251
Number of pages9
Issue number2
StatePublished - Jan 24 1997

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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