TY - JOUR
T1 - Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice
AU - Klein, Sabra L.
AU - Kriegsfeld, Lance J.
AU - Hairston, Joyce E.
AU - Rau, Vinuta
AU - Nelson, Randy J.
AU - Yarowsky, Paul J.
PY - 1996/10
Y1 - 1996/10
N2 - In the present study, segmental trisomy 16 (Ts65Dn) mice, an animal model of Down Syndrome (DS), were examined for sensorimotor; reproductive, and aggression abnormalities associated with DS. The Ts65Dn mice exhibited no sensorimotor deficits in olfactory sensitivity, visual abilities, orientation reactions, forelimb strength, postural skills, balance/coordination, climbing, or locomotion compared to genetically matched control B6EiC3HF1 mice. In mating tests, the percentage of Ts65Dn mice displaying intromissions when paired with estrous females was significantly less than that in controls. Although the percentage of Ts65Dn mice that mounted and ejaculated with an estrous female was marginally less than in controls, there were no significant differences on the other measures of reproductive behavioral performance. In aggression tests, Ts65Dn males showed increased offensive aggression in a neutral arena both when paired and among grouped males. Conversely, Ts65Dn mice exhibited less offensive aggression against an intruder in their home cage than control males. In sum, these mice possess some of the adaptive behavior abnormalities observed in DS patients; however, because the Ts65Dn mice do not have any observed sensorimotor deficits that could interfere with behavioral assessments, they may serve as a useful model for the study of behavioral impairments associated with DS.
AB - In the present study, segmental trisomy 16 (Ts65Dn) mice, an animal model of Down Syndrome (DS), were examined for sensorimotor; reproductive, and aggression abnormalities associated with DS. The Ts65Dn mice exhibited no sensorimotor deficits in olfactory sensitivity, visual abilities, orientation reactions, forelimb strength, postural skills, balance/coordination, climbing, or locomotion compared to genetically matched control B6EiC3HF1 mice. In mating tests, the percentage of Ts65Dn mice displaying intromissions when paired with estrous females was significantly less than that in controls. Although the percentage of Ts65Dn mice that mounted and ejaculated with an estrous female was marginally less than in controls, there were no significant differences on the other measures of reproductive behavioral performance. In aggression tests, Ts65Dn males showed increased offensive aggression in a neutral arena both when paired and among grouped males. Conversely, Ts65Dn mice exhibited less offensive aggression against an intruder in their home cage than control males. In sum, these mice possess some of the adaptive behavior abnormalities observed in DS patients; however, because the Ts65Dn mice do not have any observed sensorimotor deficits that could interfere with behavioral assessments, they may serve as a useful model for the study of behavioral impairments associated with DS.
KW - Agonism
KW - Animal models
KW - Behavioral genetics
KW - Down Syndrome
KW - Mating
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U2 - 10.1016/0031-9384(96)00218-1
DO - 10.1016/0031-9384(96)00218-1
M3 - Article
C2 - 8884947
AN - SCOPUS:0030271334
SN - 0031-9384
VL - 60
SP - 1159
EP - 1164
JO - Physiology and Behavior
JF - Physiology and Behavior
IS - 4
ER -