Characterization of post-infarct scars in a porcine model - A combined experimental and theoretical study

Mihaela Pop; Maxime Sermesant; Tommaso Mansi; Eugene Crystal; Jay Detsky; Yuesong Yang; Paul Fefer; Elliot R. McVeigh; Alexander Dick; Nicholas Ayache; Graham A. Wright

doi:10.1007/978-3-642-01932-6_1

Characterization of post-infarct scars in a porcine model - A combined experimental and theoretical study

Mihaela Pop, Maxime Sermesant, Tommaso Mansi, Eugene Crystal, Jay Detsky, Yuesong Yang, Paul Fefer, Elliot R. McVeigh, Alexander Dick, Nicholas Ayache, Graham A. Wright

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

Arrhythmias are often associated with healing infarcts and could arise from the border zone of the scars. The main purpose of this work was to characterize the infarct scars using in vivo electro-anatomic CARTO maps (recorded in sinus rhythm) and high-resolution ex-vivo MR images in a porcine model of chronic infarct. The MR images were segmented into scar, peri-infarct and healthy ventricular tissue, and, in select slices, the results of segmentation were validated against histology. Further, the segmented volumes and associated fiber directions (derived from diffusion-weighted (DW) MRI as well as from synthetic models), were used as input to a simple two-variable mathematical model that calculates the propagation of depolarization waves and isochronal maps; and these isochronal maps were compared to the measured ones. We further correlated the size of the scar measured during the electrophysiology (EP) study with scar dimensions obtained from MRI using ex-vivo DW-MRI methods. Finally, we present preliminary results from a qualitative comparison between the scar delineation from ex vivo and in vivo MR images.

Original language	English (US)
Title of host publication	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages	1-10
Number of pages	10
Volume	5528
DOIs	https://doi.org/10.1007/978-3-642-01932-6_1
State	Published - 2009
Event	5th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2009 - Nice, France Duration: Jun 3 2009 → Jun 5 2009

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	5528
ISSN (Print)	03029743
ISSN (Electronic)	16113349

Other

Other	5th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2009
Country/Territory	France
City	Nice
Period	6/3/09 → 6/5/09

Keywords

Cardiac MR imaging
Computer modeling
Electrophysiology

ASJC Scopus subject areas

General Computer Science
Theoretical Computer Science

Access to Document

10.1007/978-3-642-01932-6_1

Cite this

Pop, M., Sermesant, M., Mansi, T., Crystal, E., Detsky, J., Yang, Y., Fefer, P., McVeigh, E. R., Dick, A., Ayache, N., & Wright, G. A. (2009). Characterization of post-infarct scars in a porcine model - A combined experimental and theoretical study. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 5528, pp. 1-10). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 5528). https://doi.org/10.1007/978-3-642-01932-6_1

Characterization of post-infarct scars in a porcine model - A combined experimental and theoretical study. / Pop, Mihaela; Sermesant, Maxime; Mansi, Tommaso et al.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 5528 2009. p. 1-10 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 5528).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Pop, M, Sermesant, M, Mansi, T, Crystal, E, Detsky, J, Yang, Y, Fefer, P, McVeigh, ER, Dick, A, Ayache, N & Wright, GA 2009, Characterization of post-infarct scars in a porcine model - A combined experimental and theoretical study. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). vol. 5528, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 5528, pp. 1-10, 5th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2009, Nice, France, 6/3/09. https://doi.org/10.1007/978-3-642-01932-6_1

Pop M, Sermesant M, Mansi T, Crystal E, Detsky J, Yang Y et al. Characterization of post-infarct scars in a porcine model - A combined experimental and theoretical study. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 5528. 2009. p. 1-10. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/978-3-642-01932-6_1

Pop, Mihaela ; Sermesant, Maxime ; Mansi, Tommaso et al. / Characterization of post-infarct scars in a porcine model - A combined experimental and theoretical study. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 5528 2009. pp. 1-10 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

@inproceedings{3a2f1836e0164d42867050a9d677aeae,

title = "Characterization of post-infarct scars in a porcine model - A combined experimental and theoretical study",

abstract = "Arrhythmias are often associated with healing infarcts and could arise from the border zone of the scars. The main purpose of this work was to characterize the infarct scars using in vivo electro-anatomic CARTO maps (recorded in sinus rhythm) and high-resolution ex-vivo MR images in a porcine model of chronic infarct. The MR images were segmented into scar, peri-infarct and healthy ventricular tissue, and, in select slices, the results of segmentation were validated against histology. Further, the segmented volumes and associated fiber directions (derived from diffusion-weighted (DW) MRI as well as from synthetic models), were used as input to a simple two-variable mathematical model that calculates the propagation of depolarization waves and isochronal maps; and these isochronal maps were compared to the measured ones. We further correlated the size of the scar measured during the electrophysiology (EP) study with scar dimensions obtained from MRI using ex-vivo DW-MRI methods. Finally, we present preliminary results from a qualitative comparison between the scar delineation from ex vivo and in vivo MR images.",

keywords = "Cardiac MR imaging, Computer modeling, Electrophysiology",

author = "Mihaela Pop and Maxime Sermesant and Tommaso Mansi and Eugene Crystal and Jay Detsky and Yuesong Yang and Paul Fefer and McVeigh, {Elliot R.} and Alexander Dick and Nicholas Ayache and Wright, {Graham A.}",

year = "2009",

doi = "10.1007/978-3-642-01932-6_1",

language = "English (US)",

isbn = "3642019315",

volume = "5528",

series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",

pages = "1--10",

booktitle = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",

note = "5th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2009 ; Conference date: 03-06-2009 Through 05-06-2009",

}

TY - GEN

T1 - Characterization of post-infarct scars in a porcine model - A combined experimental and theoretical study

AU - Pop, Mihaela

AU - Sermesant, Maxime

AU - Mansi, Tommaso

AU - Crystal, Eugene

AU - Detsky, Jay

AU - Yang, Yuesong

AU - Fefer, Paul

AU - McVeigh, Elliot R.

AU - Dick, Alexander

AU - Ayache, Nicholas

AU - Wright, Graham A.

PY - 2009

Y1 - 2009

N2 - Arrhythmias are often associated with healing infarcts and could arise from the border zone of the scars. The main purpose of this work was to characterize the infarct scars using in vivo electro-anatomic CARTO maps (recorded in sinus rhythm) and high-resolution ex-vivo MR images in a porcine model of chronic infarct. The MR images were segmented into scar, peri-infarct and healthy ventricular tissue, and, in select slices, the results of segmentation were validated against histology. Further, the segmented volumes and associated fiber directions (derived from diffusion-weighted (DW) MRI as well as from synthetic models), were used as input to a simple two-variable mathematical model that calculates the propagation of depolarization waves and isochronal maps; and these isochronal maps were compared to the measured ones. We further correlated the size of the scar measured during the electrophysiology (EP) study with scar dimensions obtained from MRI using ex-vivo DW-MRI methods. Finally, we present preliminary results from a qualitative comparison between the scar delineation from ex vivo and in vivo MR images.

AB - Arrhythmias are often associated with healing infarcts and could arise from the border zone of the scars. The main purpose of this work was to characterize the infarct scars using in vivo electro-anatomic CARTO maps (recorded in sinus rhythm) and high-resolution ex-vivo MR images in a porcine model of chronic infarct. The MR images were segmented into scar, peri-infarct and healthy ventricular tissue, and, in select slices, the results of segmentation were validated against histology. Further, the segmented volumes and associated fiber directions (derived from diffusion-weighted (DW) MRI as well as from synthetic models), were used as input to a simple two-variable mathematical model that calculates the propagation of depolarization waves and isochronal maps; and these isochronal maps were compared to the measured ones. We further correlated the size of the scar measured during the electrophysiology (EP) study with scar dimensions obtained from MRI using ex-vivo DW-MRI methods. Finally, we present preliminary results from a qualitative comparison between the scar delineation from ex vivo and in vivo MR images.

KW - Cardiac MR imaging

KW - Computer modeling

KW - Electrophysiology

UR - http://www.scopus.com/inward/record.url?scp=68949132836&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68949132836&partnerID=8YFLogxK

U2 - 10.1007/978-3-642-01932-6_1

DO - 10.1007/978-3-642-01932-6_1

M3 - Conference contribution

AN - SCOPUS:68949132836

SN - 3642019315

SN - 9783642019319

VL - 5528

T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

SP - 1

EP - 10

BT - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

T2 - 5th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2009

Y2 - 3 June 2009 through 5 June 2009

ER -

Characterization of post-infarct scars in a porcine model - A combined experimental and theoretical study

Abstract

Publication series

Other

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this