Characterization of nipah virus from outbreaks in Bangladesh, 2008-2010

Michael K. Lo; Luis Lowe; Kimberly B. Hummel; Hossain M.S. Sazzad; Emily S. Gurley; M. Jahangir Hossain; Stephen P. Luby; David M. Miller; James A. Comer; Pierre E. Rollin; William J. Bellini; Paul A. Rota

doi:10.3201/eid1802.111492

Characterization of nipah virus from outbreaks in Bangladesh, 2008-2010

Michael K. Lo, Luis Lowe, Kimberly B. Hummel, Hossain M.S. Sazzad, Emily S. Gurley, M. Jahangir Hossain, Stephen P. Luby, David M. Miller, James A. Comer, Pierre E. Rollin, William J. Bellini, Paul A. Rota

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes fatal encephalitis in humans. The initial outbreak of NiV infection occurred in Malaysia and Singapore in 1998-1999; relatively small, sporadic outbreaks among humans have occurred in Bangladesh since 2001. We characterized the complete genomic sequences of identical NiV isolates from 2 patients in 2008 and partial genomic sequences of throat swab samples from 3 patients in 2010, all from Bangladesh. All sequences from patients in Bangladesh comprised a distinct genetic group. However, the detection of 3 genetically distinct sequences from patients in the districts of Faridpur and Gopalganj indicated multiple co-circulating lineages in a localized region over a short time (January-March 2010). Sequence comparisons between the open reading frames of all available NiV genes led us to propose a standardized protocol for genotyping NiV; this protcol provides a simple and accurate way to classify current and future NiV sequences.

Original language	English (US)
Pages (from-to)	248-255
Number of pages	8
Journal	Emerging infectious diseases
Volume	18
Issue number	2
DOIs	https://doi.org/10.3201/eid1802.111492
State	Published - Feb 2012
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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title = "Characterization of nipah virus from outbreaks in Bangladesh, 2008-2010",

abstract = "Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes fatal encephalitis in humans. The initial outbreak of NiV infection occurred in Malaysia and Singapore in 1998-1999; relatively small, sporadic outbreaks among humans have occurred in Bangladesh since 2001. We characterized the complete genomic sequences of identical NiV isolates from 2 patients in 2008 and partial genomic sequences of throat swab samples from 3 patients in 2010, all from Bangladesh. All sequences from patients in Bangladesh comprised a distinct genetic group. However, the detection of 3 genetically distinct sequences from patients in the districts of Faridpur and Gopalganj indicated multiple co-circulating lineages in a localized region over a short time (January-March 2010). Sequence comparisons between the open reading frames of all available NiV genes led us to propose a standardized protocol for genotyping NiV; this protcol provides a simple and accurate way to classify current and future NiV sequences.",

author = "Lo, {Michael K.} and Luis Lowe and Hummel, {Kimberly B.} and Sazzad, {Hossain M.S.} and Gurley, {Emily S.} and Hossain, {M. Jahangir} and Luby, {Stephen P.} and Miller, {David M.} and Comer, {James A.} and Rollin, {Pierre E.} and Bellini, {William J.} and Rota, {Paul A.}",

year = "2012",

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doi = "10.3201/eid1802.111492",

language = "English (US)",

volume = "18",

pages = "248--255",

journal = "Emerging infectious diseases",

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AU - Lo, Michael K.

AU - Lowe, Luis

AU - Hummel, Kimberly B.

AU - Sazzad, Hossain M.S.

AU - Gurley, Emily S.

AU - Hossain, M. Jahangir

AU - Luby, Stephen P.

AU - Miller, David M.

AU - Comer, James A.

AU - Rollin, Pierre E.

AU - Bellini, William J.

AU - Rota, Paul A.

PY - 2012/2

Y1 - 2012/2

N2 - Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes fatal encephalitis in humans. The initial outbreak of NiV infection occurred in Malaysia and Singapore in 1998-1999; relatively small, sporadic outbreaks among humans have occurred in Bangladesh since 2001. We characterized the complete genomic sequences of identical NiV isolates from 2 patients in 2008 and partial genomic sequences of throat swab samples from 3 patients in 2010, all from Bangladesh. All sequences from patients in Bangladesh comprised a distinct genetic group. However, the detection of 3 genetically distinct sequences from patients in the districts of Faridpur and Gopalganj indicated multiple co-circulating lineages in a localized region over a short time (January-March 2010). Sequence comparisons between the open reading frames of all available NiV genes led us to propose a standardized protocol for genotyping NiV; this protcol provides a simple and accurate way to classify current and future NiV sequences.

AB - Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes fatal encephalitis in humans. The initial outbreak of NiV infection occurred in Malaysia and Singapore in 1998-1999; relatively small, sporadic outbreaks among humans have occurred in Bangladesh since 2001. We characterized the complete genomic sequences of identical NiV isolates from 2 patients in 2008 and partial genomic sequences of throat swab samples from 3 patients in 2010, all from Bangladesh. All sequences from patients in Bangladesh comprised a distinct genetic group. However, the detection of 3 genetically distinct sequences from patients in the districts of Faridpur and Gopalganj indicated multiple co-circulating lineages in a localized region over a short time (January-March 2010). Sequence comparisons between the open reading frames of all available NiV genes led us to propose a standardized protocol for genotyping NiV; this protcol provides a simple and accurate way to classify current and future NiV sequences.

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JF - Emerging infectious diseases

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Characterization of nipah virus from outbreaks in Bangladesh, 2008-2010

Abstract

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