Characterization of Lifestyle in Spinocerebellar Ataxia Type 3 and Association with Disease Severity

Holger Hengel; Peter Martus; Jennifer Faber; Hector Garcia-Moreno; Nita Solanky; Paola Giunti; Thomas Klockgether; Kathrin Reetz; Bart P. van de Warrenburg; Luís Pereira de Almeida; Magda M. Santana; Cristina Januário; Patrick Silva; Andreas Thieme; Jon Infante; Jeroen de Vries; Manuela Lima; Ana F. Ferreira; Khalaf Bushara; Heike Jacobi; Chiadi Onyike; Jeremy D. Schmahmann; Jeannette Hübener-Schmid; Matthis Synofzik; Ludger Schöls

doi:10.1002/mds.28844

Characterization of Lifestyle in Spinocerebellar Ataxia Type 3 and Association with Disease Severity

Holger Hengel, Peter Martus, Jennifer Faber, Hector Garcia-Moreno, Nita Solanky, Paola Giunti, Thomas Klockgether, Kathrin Reetz, Bart P. van de Warrenburg, Luís Pereira de Almeida, Magda M. Santana, Cristina Januário, Patrick Silva, Andreas Thieme, Jon Infante, Jeroen de Vries, Manuela Lima, Ana F. Ferreira, Khalaf Bushara, Heike JacobiChiadi Onyike, Jeremy D. Schmahmann, Jeannette Hübener-Schmid, Matthis Synofzik, Ludger Schöls

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Lifestyle could influence the course of hereditary ataxias, but representative data are missing. Objective: The objective of this study was to characterize lifestyle in spinocerebellar ataxia type 3 (SCA3) and investigate possible associations with disease parameters. Methods: In a prospective cohort study, data on smoking, alcohol consumption, physical activity, physiotherapy, and body mass index (BMI) were collected from 243 patients with SCA3 and 119 controls and tested for associations with age of onset, disease severity, and progression. Results: Compared with controls, patients with SCA3 were less active and consumed less alcohol. Less physical activity and alcohol abstinence were associated with more severe disease, but not with progression rates or age of onset. Smoking, BMI, or physiotherapy did not correlate with disease parameters. Conclusion: Differences in lifestyle factors of patients with SCA3 and controls as well as associations of lifestyle factors with disease severity are likely driven by the influence of symptoms on behavior. No association between lifestyle and disease progression was detected.

Original language	English (US)
Pages (from-to)	405-410
Number of pages	6
Journal	Movement Disorders
Volume	37
Issue number	2
DOIs	https://doi.org/10.1002/mds.28844
State	Published - Feb 2022

Keywords

SCA3
alcohol
body mass index
lifestyle
physical activity

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.28844

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Hengel, H., Martus, P., Faber, J., Garcia-Moreno, H., Solanky, N., Giunti, P., Klockgether, T., Reetz, K., van de Warrenburg, B. P., Pereira de Almeida, L., Santana, M. M., Januário, C., Silva, P., Thieme, A., Infante, J., de Vries, J., Lima, M., Ferreira, A. F., Bushara, K., ... Schöls, L. (2022). Characterization of Lifestyle in Spinocerebellar Ataxia Type 3 and Association with Disease Severity. Movement Disorders, 37(2), 405-410. https://doi.org/10.1002/mds.28844

Hengel, H, Martus, P, Faber, J, Garcia-Moreno, H, Solanky, N, Giunti, P, Klockgether, T, Reetz, K, van de Warrenburg, BP, Pereira de Almeida, L, Santana, MM, Januário, C, Silva, P, Thieme, A, Infante, J, de Vries, J, Lima, M, Ferreira, AF, Bushara, K, Jacobi, H, Onyike, C, Schmahmann, JD, Hübener-Schmid, J, Synofzik, M & Schöls, L 2022, 'Characterization of Lifestyle in Spinocerebellar Ataxia Type 3 and Association with Disease Severity', Movement Disorders, vol. 37, no. 2, pp. 405-410. https://doi.org/10.1002/mds.28844

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abstract = "Background: Lifestyle could influence the course of hereditary ataxias, but representative data are missing. Objective: The objective of this study was to characterize lifestyle in spinocerebellar ataxia type 3 (SCA3) and investigate possible associations with disease parameters. Methods: In a prospective cohort study, data on smoking, alcohol consumption, physical activity, physiotherapy, and body mass index (BMI) were collected from 243 patients with SCA3 and 119 controls and tested for associations with age of onset, disease severity, and progression. Results: Compared with controls, patients with SCA3 were less active and consumed less alcohol. Less physical activity and alcohol abstinence were associated with more severe disease, but not with progression rates or age of onset. Smoking, BMI, or physiotherapy did not correlate with disease parameters. Conclusion: Differences in lifestyle factors of patients with SCA3 and controls as well as associations of lifestyle factors with disease severity are likely driven by the influence of symptoms on behavior. No association between lifestyle and disease progression was detected.",

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note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society",

year = "2022",

month = feb,

doi = "10.1002/mds.28844",

language = "English (US)",

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AU - Hengel, Holger

AU - Martus, Peter

AU - Faber, Jennifer

AU - Garcia-Moreno, Hector

AU - Solanky, Nita

AU - Giunti, Paola

AU - Klockgether, Thomas

AU - Reetz, Kathrin

AU - van de Warrenburg, Bart P.

AU - Pereira de Almeida, Luís

AU - Santana, Magda M.

AU - Januário, Cristina

AU - Silva, Patrick

AU - Thieme, Andreas

AU - Infante, Jon

AU - de Vries, Jeroen

AU - Lima, Manuela

AU - Ferreira, Ana F.

AU - Bushara, Khalaf

AU - Jacobi, Heike

AU - Onyike, Chiadi

AU - Schmahmann, Jeremy D.

AU - Hübener-Schmid, Jeannette

AU - Synofzik, Matthis

AU - Schöls, Ludger

PY - 2022/2

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N2 - Background: Lifestyle could influence the course of hereditary ataxias, but representative data are missing. Objective: The objective of this study was to characterize lifestyle in spinocerebellar ataxia type 3 (SCA3) and investigate possible associations with disease parameters. Methods: In a prospective cohort study, data on smoking, alcohol consumption, physical activity, physiotherapy, and body mass index (BMI) were collected from 243 patients with SCA3 and 119 controls and tested for associations with age of onset, disease severity, and progression. Results: Compared with controls, patients with SCA3 were less active and consumed less alcohol. Less physical activity and alcohol abstinence were associated with more severe disease, but not with progression rates or age of onset. Smoking, BMI, or physiotherapy did not correlate with disease parameters. Conclusion: Differences in lifestyle factors of patients with SCA3 and controls as well as associations of lifestyle factors with disease severity are likely driven by the influence of symptoms on behavior. No association between lifestyle and disease progression was detected.

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Characterization of Lifestyle in Spinocerebellar Ataxia Type 3 and Association with Disease Severity

Abstract

Keywords

ASJC Scopus subject areas

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