Characterization of cortical spreading depression by imaging of intrinsic optical signals

R. S. Yoon, P. W. Tsang, F. A. Lenz, H. C. Kwan

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The spatiotemporal progression of cortical spreading depression was investigated by imaging of activity-dependent intrinsic optical signals in rat sensorimotor cortex. In contrast to the traditional conception of a uniformly propagating event, the evolution of the spreading depression was characterized by an asymmetrical propagating wavefront and a non-uniform dispersion of optical signals behind the wavefront. As these optical signals are a reflection of underlying molecular and metabolic processes, the imaging approach to spreading depression might constitute a useful technique for investigating the functional organization as well the pathophysiology of the cerebral cortex.

Original languageEnglish (US)
Pages (from-to)2671-2674
Number of pages4
Issue number15-17
StatePublished - 1996


  • Cerebral cortex
  • Imaging
  • Intrinsic optical signals
  • Rat
  • Spreading depression

ASJC Scopus subject areas

  • Neuroscience(all)


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