Characterization of a Mycobacterium smegmatis mutant that is simultaneously resistant to D-cycloserine and vancomycin

Marcy Peteroy; Anatoly Severin; Frances Zhao; Dalya Rosner; Uri Lopatin; Hataichanouk Scherman; Aimee Belanger; Bohdan Harvey; Graham F. Hatfull; Patrick J. Brennan; Nancy D. Connell

doi:10.1128/AAC.44.6.1701-1704.2000

Characterization of a Mycobacterium smegmatis mutant that is simultaneously resistant to D-cycloserine and vancomycin

Marcy Peteroy, Anatoly Severin, Frances Zhao, Dalya Rosner, Uri Lopatin, Hataichanouk Scherman, Aimee Belanger, Bohdan Harvey, Graham F. Hatfull, Patrick J. Brennan, Nancy D. Connell

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A mutant of Mycobacterium smegmatis has been isolated that is simultaneously resistant to both D-cycloserine (D-CS) and vancomycin. Genetic complementation with a PBP4 homolog restores sensitivity to both drugs. Resistance to D-CS and vancomycin in this mutant is most likely due to a novel mechanism involving peptidoglycan assembly at the cell surface.

Original language	English (US)
Pages (from-to)	1701-1704
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	44
Issue number	6
DOIs	https://doi.org/10.1128/AAC.44.6.1701-1704.2000
State	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.44.6.1701-1704.2000

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Peteroy, M., Severin, A., Zhao, F., Rosner, D., Lopatin, U., Scherman, H., Belanger, A., Harvey, B., Hatfull, G. F., Brennan, P. J., & Connell, N. D. (2000). Characterization of a Mycobacterium smegmatis mutant that is simultaneously resistant to D-cycloserine and vancomycin. Antimicrobial agents and chemotherapy, 44(6), 1701-1704. https://doi.org/10.1128/AAC.44.6.1701-1704.2000

Peteroy, M, Severin, A, Zhao, F, Rosner, D, Lopatin, U, Scherman, H, Belanger, A, Harvey, B, Hatfull, GF, Brennan, PJ & Connell, ND 2000, 'Characterization of a Mycobacterium smegmatis mutant that is simultaneously resistant to D-cycloserine and vancomycin', Antimicrobial agents and chemotherapy, vol. 44, no. 6, pp. 1701-1704. https://doi.org/10.1128/AAC.44.6.1701-1704.2000

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author = "Marcy Peteroy and Anatoly Severin and Frances Zhao and Dalya Rosner and Uri Lopatin and Hataichanouk Scherman and Aimee Belanger and Bohdan Harvey and Hatfull, {Graham F.} and Brennan, {Patrick J.} and Connell, {Nancy D.}",

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AU - Peteroy, Marcy

AU - Severin, Anatoly

AU - Zhao, Frances

AU - Rosner, Dalya

AU - Lopatin, Uri

AU - Scherman, Hataichanouk

AU - Belanger, Aimee

AU - Harvey, Bohdan

AU - Hatfull, Graham F.

AU - Brennan, Patrick J.

AU - Connell, Nancy D.

PY - 2000

Y1 - 2000

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AB - A mutant of Mycobacterium smegmatis has been isolated that is simultaneously resistant to both D-cycloserine (D-CS) and vancomycin. Genetic complementation with a PBP4 homolog restores sensitivity to both drugs. Resistance to D-CS and vancomycin in this mutant is most likely due to a novel mechanism involving peptidoglycan assembly at the cell surface.

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JF - Antimicrobial agents and chemotherapy

IS - 6

ER -

Characterization of a Mycobacterium smegmatis mutant that is simultaneously resistant to D-cycloserine and vancomycin

Abstract

ASJC Scopus subject areas

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