Characteristics of the bursting pattern of action potentials that occurs in the thalamus of patients with central pain

Frederick A. Lenz; Hon C. Kwan; Jonathan O. Dostrovsky; Ronald R. Tasker

doi:10.1016/0006-8993(89)91088-3

Characteristics of the bursting pattern of action potentials that occurs in the thalamus of patients with central pain

Frederick A. Lenz, Hon C. Kwan, Jonathan O. Dostrovsky, Ronald R. Tasker

School of Medicine

Research output: Contribution to journal › Article › peer-review

239 Scopus citations

Abstract

Neurons in the somatosensory thalamus of patients with central pain following spinal cord injury fire in bursts of action potentials more frequently than do similar neurons in patients without pain. Furthermore, the characteristic firing pattern within these bursts is similar to that which is shown to be associated with the occurence of calcium spikes in intracellular studies of thalamic nuclei. This finding may have significant implications for the etiology and treatment of central pain states.

Original language	English (US)
Pages (from-to)	357-360
Number of pages	4
Journal	Brain research
Volume	496
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(89)91088-3
State	Published - Sep 4 1989

Keywords

Action potential burst
Calcium
Human thalamus
Nervous system plasticity
Pain
Slow wave sleep
Spinal cord injury

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(89)91088-3

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abstract = "Neurons in the somatosensory thalamus of patients with central pain following spinal cord injury fire in bursts of action potentials more frequently than do similar neurons in patients without pain. Furthermore, the characteristic firing pattern within these bursts is similar to that which is shown to be associated with the occurence of calcium spikes in intracellular studies of thalamic nuclei. This finding may have significant implications for the etiology and treatment of central pain states.",

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AU - Dostrovsky, Jonathan O.

AU - Tasker, Ronald R.

PY - 1989/9/4

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N2 - Neurons in the somatosensory thalamus of patients with central pain following spinal cord injury fire in bursts of action potentials more frequently than do similar neurons in patients without pain. Furthermore, the characteristic firing pattern within these bursts is similar to that which is shown to be associated with the occurence of calcium spikes in intracellular studies of thalamic nuclei. This finding may have significant implications for the etiology and treatment of central pain states.

AB - Neurons in the somatosensory thalamus of patients with central pain following spinal cord injury fire in bursts of action potentials more frequently than do similar neurons in patients without pain. Furthermore, the characteristic firing pattern within these bursts is similar to that which is shown to be associated with the occurence of calcium spikes in intracellular studies of thalamic nuclei. This finding may have significant implications for the etiology and treatment of central pain states.

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KW - Calcium

KW - Human thalamus

KW - Nervous system plasticity

KW - Pain

KW - Slow wave sleep

KW - Spinal cord injury

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Characteristics of the bursting pattern of action potentials that occurs in the thalamus of patients with central pain

Abstract

Keywords

ASJC Scopus subject areas

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