Characteristics of nondisabled older persons who perform poorly in objective tests of lower extremity function

Luigi Ferrucci, Brenda W J H Penninx, Suzanne G. Leveille, Maria Chiara Corti, Marco Pahor, Robert Wallace, Tamara B. Harris, Richard J. Havlik, Jack M. Guralnik

Research output: Contribution to journalArticlepeer-review

132 Scopus citations


OBJECTIVES: It has been suggested that nondisabled older persons with poor performance of lower extremity function are ideal targets for interventions of disability prevention. However, health-related factors associated with poor performance are largely unknown. Using data from a representative sample of nondisabled older persons, this study identifies the diseases and biological markers that characterize this group of the population. DESIGN AND PARTICIPANTS: A total of 3381 persons aged 71 or older, interviewed and administered a battery of physical performance tests at the sixth annual follow-up of the Established Populations for Epidemiologic Studies of the Elderly (EPESE), who reported no need for help in walking 1/4 mile or climbing stairs. MEASUREMENTS: Lower extremity performance was measured using a short battery of tests including assessment of standing balance, a timed 2.4-m walk, and timed test of rising 5 times from a chair. Chronic conditions were ascertained as self-report of a physician diagnosis. Data on previous hospitalizations were obtained from the Medicare data-base. Nonfasting blood samples were obtained and processed with standard methods. RESULTS: In a multivariate analysis, older age, female gender, higher BMI, history of hip fracture and diabetes, one or more hospital admissions for acute infection in the last 3 years, lower levels of hemoglobin and albumin, and higher leukocytes and γ-glutamyl transferase were all associated independently with poor performance. CONCLUSIONS: Screening for older patients who are not disabled but have poor lower extremity performance selects a subgroup of the population with a high percentage of women, high prevalence of diabetes and hip fracture, and high levels of biological markers of inflammation. This group represents about 10% of the US population 70 to 90 years old. These findings should be considered in planning specifically tailored interventions for disability prevention in this subgroup.

Original languageEnglish (US)
Pages (from-to)1102-1110
Number of pages9
JournalJournal of the American Geriatrics Society
Issue number9
StatePublished - 2000
Externally publishedYes


  • Aging
  • Disability
  • Lower extremity
  • Physical performance
  • Prevention of disability

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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