Characteristics of 400-meter walk test performance and subsequent mortality in older adults

Sonja Vestergaard, Kushang V. Patel, Stefania Bandinelli, Luigi Ferrucci, Jack M. Guralnik

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


The purpose was to examine the relationship between performance in the 400-meter walking test and mortality. Data are from a population-based sample of 948 Italian men and women ≥65 years. The main outcome measures that were assessed comprised time to complete the 400-meter walk, 20-meter lap time coefficient of variation, need to rest during the test, and ability to complete the walk. All-cause mortality was ascertained over a 6-year follow-up period. Data were analyzed with proportional hazard logistic and linear regression analyses. In age- and sex-adjusted analyses, all 400-meter walking test variables except need to rest were associated with mortality. After further adjusting for the Mini-Mental State Examination, symptoms of depression, education, smoking, body mass index, being sedentary/minimally active, disease burden, and lower extremity performance (Short Physical Performance Battery score), both time to complete the 400-meter walk and lap time coefficient of variation were significant independent predictors of mortality. We conclude that multiple aspects of performance in the 400-meter walk test provide complementary information on mortality prognosis in older persons.

Original languageEnglish (US)
Pages (from-to)177-184
Number of pages8
JournalRejuvenation Research
Issue number3
StatePublished - Jun 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology


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