Characteristics Associated with Autism Spectrum Disorder Risk in Individuals with Down Syndrome

The Down Syndrome Cognition Project

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


We examined autism spectrum disorder (ASD) risk in a large national sample of 203 individuals with Down syndrome, 6–25 years old, to determine the association of ASD risk with age, sex, IQ, adaptive behaviors, and maladaptive behaviors. We used a two-pronged approach by (1) considering ASD symptomatology continuously across the sample of individuals with DS and examining associations with each characteristic, and (2) dichotomizing our sample into high and low ASD risk groups and comparing groups on each characteristic. The pattern of results was largely similar across both types of analyses. ASD symptomatology/risk was negatively associated with IQ and adaptive behaviors and positively associated with certain types of maladaptive behaviors. Clinical implications for screening and therapeutic purposes are discussed.

Original languageEnglish (US)
Pages (from-to)3543-3556
Number of pages14
JournalJournal of Autism and Developmental Disorders
Issue number9
StatePublished - Sep 15 2019


  • Autism spectrum disorder
  • Down syndrome
  • Intellectual disability
  • Maladaptive behavior
  • Psychiatric comorbidities

ASJC Scopus subject areas

  • Developmental and Educational Psychology


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