@inbook{557bd508692f44cabc6abe644eaad0d9,
title = "Chapter 4 Alzheimer's Disease in Adults with Down Syndrome",
abstract = "Down syndrome is associated with increased mortality rates due to congenital cardiac defects and leukemia early in life, and with Alzheimer's disease and a tendency toward premature aging later in life. Alzheimer's disease was once considered an inexorable result of growing old with Down syndrome, but recent data indicate that risk does not reach 100\%. Although some individuals exhibit signs and symptoms of Alzheimer's disease in their 40s, other individuals have reached the age of 70 without developing dementia. This chapter presents a wealth of data from a longstanding longitudinal study with the overall objective of understanding and recounting the mechanisms responsible for these substantial individual differences.",
author = "Zigman, \{Warren B.\} and Devenny, \{Darlynne A.\} and Krinsky-McHale, \{Sharon J.\} and Jenkins, \{Edmund C.\} and Urv, \{Tiina K.\} and Jerzy Wegiel and Nicole Schupf and Wayne Silverman",
note = "Funding Information: Supported by NIH grants AG014763, HD35897, HD37425, and HD43960; by funds provided by the National Down Syndrome Society in collaboration with the NIH; by Alzheimer's Association grants IIRG‐07‐60558, IIRG‐99‐1598, and IIRG‐96‐077; and by New York State through its Office of Mental Retardation and Developmental Disabilities.",
year = "2008",
doi = "10.1016/S0074-7750(08)00004-9",
language = "English (US)",
isbn = "9780123744760",
series = "International Review of Research in Mental Retardation",
pages = "103--145",
editor = "Glidden, \{Laraine Masters\}",
booktitle = "International Review of Research in Mental Retardation",
}