Changes in the concentration of breath ammonia in response to exercise: A preliminary investigation

Steven F. Solga, Matthew Mudalel, Lisa A. Spacek, Rafal Lewicki, Frank K. Tittel, Claudio Loccioni, Adolfo Russo, Alessandro Ragnoni, Terence H. Risby

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Breath ammonia has proven to be a difficult compound to measure accurately. The goal of this study was to evaluate the effects that the physiological intervention, exercise, had on the levels of breath ammonia. The effects of vigorous exercise (4000 m indoor row) in 13 participants were studied and increases in breath ammonia were observed in all participants. Mean pre-exercise concentrations of ammonia were 670 pmol ml-1CO2(SD, 446) and these concentrations increased to post-exercise maxima of 1499 pmol ml-1CO2(SD, 730), p < 0.0001. The mean increase in ammonia concentrations from pre-exercise to maximum achieved in conditioned (1362 pmol ml-1CO2) versus non-conditioned rowers (591 pmol ml-1CO2) were found to be statistically different, p = 0.029. Taken together, these results demonstrate our ability to repeatedly measure the influence of exercise on the concentration of breath ammonia.

Original languageEnglish (US)
Article number037103
JournalJournal of breath research
Issue number3
StatePublished - Sep 1 2014
Externally publishedYes


  • ammonia production
  • breath ammonia
  • exercise
  • photoacoustic spectroscopy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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