TY - JOUR
T1 - Changes in short-term health-related quality of life in women undergoing gynecologic oncologic laparotomy
T2 - An associated factor analysis
AU - Minig, Lucas
AU - Vélez, Jorge Iván
AU - Trimble, Edward L.
AU - Biffi, Roberto
AU - Maggioni, Angelo
AU - Jeffery, Diana D.
N1 - Funding Information:
Acknowledgments The authors thank Carmen Beltrami, RN; Ema-nuella D’Anna; and all the nursing staff of the Gynecologic Department, European Institute of Oncology, Milan, Italy for their active participation in the execution of this study. Finally, the authors recognize the great efforts made by Anna Attanasio (Anesthesiology Department, European Institute of Oncology, Milan, Italy) and Maira Bigioggero (data manager, Gynecologic Department, European Institute of Oncology, Milan, Italy) in retrieving the data. This research was supported, in part, by the Intramural Research Program of the National Human Genome Research Institute, National Institutes of Health.
PY - 2013/3
Y1 - 2013/3
N2 - Purpose: The primary purpose of this study is to evaluate health-related quality of life (HR-QOL) of gynecologic cancer patients undergoing laparotomy. Methods: Women who underwent laparotomy by gynecologic cancer completed the European Organization for Research and Treatment of Cancer (EORTC) Quality of life questionnaires (QLQ-C30 and QLQ-OV28) presurgery and at 1 month. Results: Of the 181 women studied between January 2007 and March 2008, 116 women (64.1 %) had ovarian cancer, 27 (14.9 %) had cervical cancer, and 29 (16.0 %) had endometrial cancer. By 1 month post-surgery, there was a significant decrease in HR-QOL on the global, abdominal/gastrointestinal (GI) score, body image, chemotherapy side effects, and other single items of the OV28 questionnaire, as well as on physical, role and social functioning, fatigue, nausea and vomiting, pain, insomnia, constipation, appetite loss, and financial difficulties items on C30 questionnaires. Emotional functioning on C30 questionnaires was significantly improved 1 month after surgery. The majority of these items persisted 1 month after surgery only in patients with ovarian cancer. Abdominal/GI score on OV28 questionnaires as well as role and physical functioning on C30 questionnaires were significantly lower between baseline and postsurgical HR-QOL in women with other gynecologic malignancies. Conclusion: The results suggest a significant impact of HR-QOL among gynecologic cancer patients 1 month after laparotomy, particularly among those with ovarian cancer.
AB - Purpose: The primary purpose of this study is to evaluate health-related quality of life (HR-QOL) of gynecologic cancer patients undergoing laparotomy. Methods: Women who underwent laparotomy by gynecologic cancer completed the European Organization for Research and Treatment of Cancer (EORTC) Quality of life questionnaires (QLQ-C30 and QLQ-OV28) presurgery and at 1 month. Results: Of the 181 women studied between January 2007 and March 2008, 116 women (64.1 %) had ovarian cancer, 27 (14.9 %) had cervical cancer, and 29 (16.0 %) had endometrial cancer. By 1 month post-surgery, there was a significant decrease in HR-QOL on the global, abdominal/gastrointestinal (GI) score, body image, chemotherapy side effects, and other single items of the OV28 questionnaire, as well as on physical, role and social functioning, fatigue, nausea and vomiting, pain, insomnia, constipation, appetite loss, and financial difficulties items on C30 questionnaires. Emotional functioning on C30 questionnaires was significantly improved 1 month after surgery. The majority of these items persisted 1 month after surgery only in patients with ovarian cancer. Abdominal/GI score on OV28 questionnaires as well as role and physical functioning on C30 questionnaires were significantly lower between baseline and postsurgical HR-QOL in women with other gynecologic malignancies. Conclusion: The results suggest a significant impact of HR-QOL among gynecologic cancer patients 1 month after laparotomy, particularly among those with ovarian cancer.
KW - Gynecologic cancer
KW - Laparotomy
KW - Quality of life
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U2 - 10.1007/s00520-012-1571-z
DO - 10.1007/s00520-012-1571-z
M3 - Article
C2 - 22930239
AN - SCOPUS:84874105800
SN - 0941-4355
VL - 21
SP - 715
EP - 726
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 3
ER -