Changes in plasma histaminase activity during normal early human pregnancy and pregnancy disorders

M. A. Beaven, J. R. Marshall, S. B. Baylin, A. Sjoerdsma

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


A sensitive isotopic assay was employed to follow the changes in plasma histaminase activity during pregnancy in patients who become pregnant following spontaneous and induced ovulation. Values in nonpregnant women ranged from 0.2 to 2.7 pmoles of histamine deaminated per milliliter of plasma per hour. In pregnant women, plasma histaminase activity began to increase 9 to 28 days following the presumed day of ovulation and then rose exponentially with a doubling time of 4 to 5 days. Peak values, 1,500 pmoles per milliliter per hour, were reached during the third trimester of pregnancy. The data suggested that the increase in histaminase activity actually started at about the same time in all patients, although the early rise in enzyme activity was not apparent in women who had high histaminase activity before pregnancy. Plasma histaminase did not rise in patients with spontaneous abortion, blighted ovum with hydatidiform degeneration, or choriocarcinoma. The high levels of chorionic gonadotropin and low levels of histaminase activity seen in patients with trophoblastic neoplasia suggest that these tests may be of value in the diagnosis of trophoblastic neoplasia early in pregnancy.

Original languageEnglish (US)
Pages (from-to)605-609
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Issue number6
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology


Dive into the research topics of 'Changes in plasma histaminase activity during normal early human pregnancy and pregnancy disorders'. Together they form a unique fingerprint.

Cite this