Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis

Timothy M. Hughes; Suzanne Craft; Laura D. Baker; Mark A. Espeland; Stephen R. Rapp; Kaycee M. Sink; Alain G. Bertoni; Gregory L. Burke; Rebecca F. Gottesman; Erin D. Michos; José A. Luchsinger; Annette L. Fitzpatrick; Kathleen M. Hayden

doi:10.1016/j.dadm.2017.03.003

Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis

Timothy M. Hughes, Suzanne Craft, Laura D. Baker, Mark A. Espeland, Stephen R. Rapp, Kaycee M. Sink, Alain G. Bertoni, Gregory L. Burke, Rebecca F. Gottesman, Erin D. Michos, José A. Luchsinger, Annette L. Fitzpatrick, Kathleen M. Hayden

School of Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background We examined whether changes in metabolic factors over 10 years were associated with cognitive performance. Methods Participants from the Multi-Ethnic Study of Atherosclerosis were followed since baseline (2000–2002) with five clinical examinations. At exam 5 (2010–2012), they received a short cognitive battery (Cognitive Abilities Screening Instrument [CASI], Digit Symbol Coding [DSC], and Digit Span [DS]). We examined associations between baseline metabolic factors and their changes over time before cognitive testing. Results Among 4392 participants, baseline metabolic disorders (fasting glucose, systolic and diastolic blood pressures) were significantly associated with poorer CASI, DSC, and DS scores measured 10 years later. Increases in blood pressure were associated with lower cognitive performance. Results did not differ by race/ethnicity and were stronger among those without the APOE ε4 allele. Conclusions Cognitive performance was associated with antecedent abnormalities in glucose metabolism and blood pressure increases. Findings appeared stronger among APOE ε4-negative participants.

Original language	English (US)
Pages (from-to)	18-25
Number of pages	8
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	8
DOIs	https://doi.org/10.1016/j.dadm.2017.03.003
State	Published - 2017

Keywords

Brain
Cognitive function
Metabolic disorders
Metabolism

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

Access to Document

10.1016/j.dadm.2017.03.003

Cite this

Hughes, T. M., Craft, S., Baker, L. D., Espeland, M. A., Rapp, S. R., Sink, K. M., Bertoni, A. G., Burke, G. L., Gottesman, R. F., Michos, E. D., Luchsinger, J. A., Fitzpatrick, A. L., & Hayden, K. M. (2017). Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 8, 18-25. https://doi.org/10.1016/j.dadm.2017.03.003

Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis. / Hughes, Timothy M.; Craft, Suzanne; Baker, Laura D. et al.
In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 8, 2017, p. 18-25.

Research output: Contribution to journal › Article › peer-review

Hughes, TM, Craft, S, Baker, LD, Espeland, MA, Rapp, SR, Sink, KM, Bertoni, AG, Burke, GL, Gottesman, RF, Michos, ED, Luchsinger, JA, Fitzpatrick, AL & Hayden, KM 2017, 'Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 8, pp. 18-25. https://doi.org/10.1016/j.dadm.2017.03.003

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abstract = "Background We examined whether changes in metabolic factors over 10 years were associated with cognitive performance. Methods Participants from the Multi-Ethnic Study of Atherosclerosis were followed since baseline (2000–2002) with five clinical examinations. At exam 5 (2010–2012), they received a short cognitive battery (Cognitive Abilities Screening Instrument [CASI], Digit Symbol Coding [DSC], and Digit Span [DS]). We examined associations between baseline metabolic factors and their changes over time before cognitive testing. Results Among 4392 participants, baseline metabolic disorders (fasting glucose, systolic and diastolic blood pressures) were significantly associated with poorer CASI, DSC, and DS scores measured 10 years later. Increases in blood pressure were associated with lower cognitive performance. Results did not differ by race/ethnicity and were stronger among those without the APOE ε4 allele. Conclusions Cognitive performance was associated with antecedent abnormalities in glucose metabolism and blood pressure increases. Findings appeared stronger among APOE ε4-negative participants.",

keywords = "Brain, Cognitive function, Metabolic disorders, Metabolism",

author = "Hughes, {Timothy M.} and Suzanne Craft and Baker, {Laura D.} and Espeland, {Mark A.} and Rapp, {Stephen R.} and Sink, {Kaycee M.} and Bertoni, {Alain G.} and Burke, {Gregory L.} and Gottesman, {Rebecca F.} and Michos, {Erin D.} and Luchsinger, {Jos{\'e} A.} and Fitzpatrick, {Annette L.} and Hayden, {Kathleen M.}",

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doi = "10.1016/j.dadm.2017.03.003",

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AU - Baker, Laura D.

AU - Espeland, Mark A.

AU - Rapp, Stephen R.

AU - Sink, Kaycee M.

AU - Bertoni, Alain G.

AU - Burke, Gregory L.

AU - Gottesman, Rebecca F.

AU - Michos, Erin D.

AU - Luchsinger, José A.

AU - Fitzpatrick, Annette L.

AU - Hayden, Kathleen M.

PY - 2017

Y1 - 2017

N2 - Background We examined whether changes in metabolic factors over 10 years were associated with cognitive performance. Methods Participants from the Multi-Ethnic Study of Atherosclerosis were followed since baseline (2000–2002) with five clinical examinations. At exam 5 (2010–2012), they received a short cognitive battery (Cognitive Abilities Screening Instrument [CASI], Digit Symbol Coding [DSC], and Digit Span [DS]). We examined associations between baseline metabolic factors and their changes over time before cognitive testing. Results Among 4392 participants, baseline metabolic disorders (fasting glucose, systolic and diastolic blood pressures) were significantly associated with poorer CASI, DSC, and DS scores measured 10 years later. Increases in blood pressure were associated with lower cognitive performance. Results did not differ by race/ethnicity and were stronger among those without the APOE ε4 allele. Conclusions Cognitive performance was associated with antecedent abnormalities in glucose metabolism and blood pressure increases. Findings appeared stronger among APOE ε4-negative participants.

AB - Background We examined whether changes in metabolic factors over 10 years were associated with cognitive performance. Methods Participants from the Multi-Ethnic Study of Atherosclerosis were followed since baseline (2000–2002) with five clinical examinations. At exam 5 (2010–2012), they received a short cognitive battery (Cognitive Abilities Screening Instrument [CASI], Digit Symbol Coding [DSC], and Digit Span [DS]). We examined associations between baseline metabolic factors and their changes over time before cognitive testing. Results Among 4392 participants, baseline metabolic disorders (fasting glucose, systolic and diastolic blood pressures) were significantly associated with poorer CASI, DSC, and DS scores measured 10 years later. Increases in blood pressure were associated with lower cognitive performance. Results did not differ by race/ethnicity and were stronger among those without the APOE ε4 allele. Conclusions Cognitive performance was associated with antecedent abnormalities in glucose metabolism and blood pressure increases. Findings appeared stronger among APOE ε4-negative participants.

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