Changes in hepatitis B virus DNA levels with acute HIV infection

Chloe L. Thio; Dale M. Netski; Jane Myung; Eric C. Seaberg; David L. Thomas

doi:10.1086/382534

Changes in hepatitis B virus DNA levels with acute HIV infection

Chloe L. Thio
, Dale M. Netski
, Jane Myung
, Eric C. Seaberg
, David L. Thomas

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

We hypothesized that acute infection with human immunodeficiency virus (HIV) would diminish immunoregulation of chronic hepatitis B (CHB), resulting in higher blood hepatitis B virus (HBV) DNA levels. To test this hypothesis, we evaluated sequential HBV DNA levels in stored serum samples obtained from 9 men with CHB who acquired HIV infection. Three patterns of changes in HBV DNA levels were noted after HIV seroconversion. One man experienced the expected increase in HBV DNA, 3 men had stable HBV DNA levels, and, unexpectedly, 5 men had a mean decrease of 6.29 log₁₀ copies/mL in the HBV DNA level, with hepatitis B e antigen no longer detectable in 4. Acute HIV infection is not consistently associated with an increased blood HBV DNA level. Additional research is needed to understand the mechanism for the unexpected reductions in HBV DNA levels associated with acute HIV infection.

Original language	English (US)
Pages (from-to)	1024-1029
Number of pages	6
Journal	Clinical Infectious Diseases
Volume	38
Issue number	7
DOIs	https://doi.org/10.1086/382534
State	Published - Apr 1 2004

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1086/382534

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title = "Changes in hepatitis B virus DNA levels with acute HIV infection",

abstract = "We hypothesized that acute infection with human immunodeficiency virus (HIV) would diminish immunoregulation of chronic hepatitis B (CHB), resulting in higher blood hepatitis B virus (HBV) DNA levels. To test this hypothesis, we evaluated sequential HBV DNA levels in stored serum samples obtained from 9 men with CHB who acquired HIV infection. Three patterns of changes in HBV DNA levels were noted after HIV seroconversion. One man experienced the expected increase in HBV DNA, 3 men had stable HBV DNA levels, and, unexpectedly, 5 men had a mean decrease of 6.29 log10 copies/mL in the HBV DNA level, with hepatitis B e antigen no longer detectable in 4. Acute HIV infection is not consistently associated with an increased blood HBV DNA level. Additional research is needed to understand the mechanism for the unexpected reductions in HBV DNA levels associated with acute HIV infection.",

author = "Thio, \{Chloe L.\} and Netski, \{Dale M.\} and Jane Myung and Seaberg, \{Eric C.\} and Thomas, \{David L.\}",

note = "Funding Information: Financial support: Johns Hopkins University Center for AIDS Research (grant P30 AI42855) and National Institutes of Health (grant DA00441 to C.T.). The Multicenter AIDS Cohort Study is funded by the National Institute of Allergy and Infectious Diseases, with additional supplemental funding from the National Cancer Institute (grants UO1-AI-35042, 5-MO1-RR-00722 [General Clinical Research Center], UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, and UO1-AI-35041).",

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AU - Netski, Dale M.

AU - Myung, Jane

AU - Seaberg, Eric C.

AU - Thomas, David L.

N1 - Funding Information: Financial support: Johns Hopkins University Center for AIDS Research (grant P30 AI42855) and National Institutes of Health (grant DA00441 to C.T.). The Multicenter AIDS Cohort Study is funded by the National Institute of Allergy and Infectious Diseases, with additional supplemental funding from the National Cancer Institute (grants UO1-AI-35042, 5-MO1-RR-00722 [General Clinical Research Center], UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, and UO1-AI-35041).

PY - 2004/4/1

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N2 - We hypothesized that acute infection with human immunodeficiency virus (HIV) would diminish immunoregulation of chronic hepatitis B (CHB), resulting in higher blood hepatitis B virus (HBV) DNA levels. To test this hypothesis, we evaluated sequential HBV DNA levels in stored serum samples obtained from 9 men with CHB who acquired HIV infection. Three patterns of changes in HBV DNA levels were noted after HIV seroconversion. One man experienced the expected increase in HBV DNA, 3 men had stable HBV DNA levels, and, unexpectedly, 5 men had a mean decrease of 6.29 log10 copies/mL in the HBV DNA level, with hepatitis B e antigen no longer detectable in 4. Acute HIV infection is not consistently associated with an increased blood HBV DNA level. Additional research is needed to understand the mechanism for the unexpected reductions in HBV DNA levels associated with acute HIV infection.

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Changes in hepatitis B virus DNA levels with acute HIV infection

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