@article{58206343699e4b71a48030adc9b7b1ed,
title = "Changes in Aβ biomarkers and associations with APOE genotype in 2 longitudinal cohorts",
abstract = "Apolipoprotein E (APOE) genotype influences onset age of Alzheimer's disease but effects on disease progression are less clear. We investigated amyloid-β (Aβ) levels and change in relationship to APOE genotype, using 2 different measures of Aβ in 2 different longitudinal cohorts. Aβ accumulation was measured using positron emission tomography (PET) imaging and 11C-Pittsburgh compound-B (PiB) in 113 Baltimore Longitudinal Study of Aging participants (mean age 77.3 years; 107 normal, 6 cognitively impaired) and cerebral spinal fluid (CSF) Aβ1-42 assays in 207 BIOCARD study participants (mean age 62 years; 195 normal, 12 cognitively impaired). Participants in both cohorts had up to 7 serial assessments (mean 2.3-2.4). PET-PiB retention increased and CSF Aβ1-42 declined longitudinally. APOE ε4 was significantly associated with higher PET-PiB retention and lower CSF Aβ1-42, independent of age and sex, but APOE genotype did not significantly affect Aβ change over time. APOE ε4 carriers may be further along in the disease process, consistent with earlier brain Aβ deposition and providing a biological basis for APOE genotype effects on onset age of Alzheimer's disease.",
keywords = "Apolipoprotein E genotype, Biomarkers, CSF Aβ, Longitudinal, PET amyloid imaging",
author = "Resnick, {Susan M.} and Murat Bilgel and Abhay Moghekar and Yang An and Qing Cai and Wang, {Mei Cheng} and Madhav Thambisetty and Prince, {Jerry L.} and Yun Zhou and Anja Soldan and Wong, {Dean F.} and O'Brien, {Richard J.} and Luigi Ferrucci and Albert, {Marilyn S.}",
note = "Funding Information: The BIOCARD study is supported in part by grants from the National Institutes of Health : U01-AG03365 , P50- AG005146 and P41-RR015241 . The BIOCARD Study consists of 7 cores with the following members: (1) the Administrative Core (Marilyn Albert, Barbara Rodzon, Richard Power), (2) the Clinical Core (Ola Selnes, Marilyn Albert, Rebecca Gottesman, Ned Sacktor, Guy McKhann, Scott Turner, Leonie Farrington, Maura Grega, Daniel D'Agostino, Sydney Feagen, David Dolan, Hillary Dolan), (3) the Imaging Core (Michael Miller, Susumu Mori, Tilak Ratnanather, Timothy Brown, Hayan Chi, Anthony Kolasny, Kenichi Oishi, Thomas Reigel, William Schneider, Laurent Younes), (4) the Biospecimen Core (Richard O'Brien, Abhay Moghekar, Richard Meehan), (5) the Informatics Core (Roberta Scherer, Curt Meinert, David Shade, Ann Ervin, Jennifer Jones, Matt Toepfner, Lauren Parlett, April Patterson, Lisa Lassiter), the (6) Biostatistics Core (Mei-Cheng Wang, Yi Lu, Qing Cai), and (7) the Neuropathology Core (Juan Troncoso, Barbara Crain, Olga Pletnikova, Gay Rudow, Karen Fisher). Funding Information: The BLSA study was supported in part by the Intramural Research Program of the NIH , National Institute on Aging and by Research and Development Contract HHSN-260-2004-00012C . We are grateful to the BLSA participants and staff for their dedication to these studies and the staff of the Johns Hopkins PET facility for their assistance. We are especially grateful to Wendy Elkins and Brieana Viscomi for their assistance with coordination and data collection for the PET-PiB studies. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
doi = "10.1016/j.neurobiolaging.2015.04.001",
language = "English (US)",
volume = "36",
pages = "2333--2339",
journal = "Neurobiology of aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "8",
}