Challenges to evidence-based prescribing in clinical practice

Muhammad Mamdani, Andrew Ching, Brian Golden, Magda Melo, Ulrich Menzefricke

Research output: Contribution to journalComment/debatepeer-review

8 Scopus citations


Although there appears to be widespread support of evidence-based medicine as a basis for rational prescribing, the challenges to it are significant and often justified. A multitude of factors other than evidence drive clinical decision-making, including patient preferences and social circumstances, presence of disease-drug and drug-drug interactions, clinical experience, competing demands from more pressing clinical conditions, marketing and promotional activity, and system-level drug policies.

Original languageEnglish (US)
Pages (from-to)704-707
Number of pages4
JournalAnnals of Pharmacotherapy
Issue number5
StatePublished - May 2008


  • Clinical practice
  • Evidence-based prescribing
  • Pharmacy practice

ASJC Scopus subject areas

  • Pharmacology (medical)


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