Challenges of Conducting a Placebo-Controlled Trial for Dysmenorrhea in Adolescents

Anne R. Davis; Lauren M. Osborne; Katharine J. O'Connell; Carolyn L. Westhoff

doi:10.1016/j.jadohealth.2006.03.019

Challenges of Conducting a Placebo-Controlled Trial for Dysmenorrhea in Adolescents

Anne R. Davis, Lauren M. Osborne, Katharine J. O'Connell, Carolyn L. Westhoff

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We recruited adolescents to study oral contraceptives versus placebo for dysmenorrhea. We anticipated high discontinuation and concerns about safety, side effects, and sexual behavior. Treatment discontinuation (11%) and loss to follow-up (1%) were lower than expected. The most common reason for nonenrollment was logistical issues (63%). Most participants remained abstinent.

Original language	English (US)
Pages (from-to)	607-609
Number of pages	3
Journal	Journal of Adolescent Health
Volume	39
Issue number	4
DOIs	https://doi.org/10.1016/j.jadohealth.2006.03.019
State	Published - Oct 2006
Externally published	Yes

Keywords

Adolescents
Dysmenorrhea
Oral contraception

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Public Health, Environmental and Occupational Health
Psychiatry and Mental health

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10.1016/j.jadohealth.2006.03.019

Cite this

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title = "Challenges of Conducting a Placebo-Controlled Trial for Dysmenorrhea in Adolescents",

abstract = "We recruited adolescents to study oral contraceptives versus placebo for dysmenorrhea. We anticipated high discontinuation and concerns about safety, side effects, and sexual behavior. Treatment discontinuation (11%) and loss to follow-up (1%) were lower than expected. The most common reason for nonenrollment was logistical issues (63%). Most participants remained abstinent.",

keywords = "Adolescents, Dysmenorrhea, Oral contraception",

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note = "Funding Information: Funding support for this study was provided by the National Institute of Child Health and Human Development Grant number R03-HD39776-RCT. The views in this manuscript do not necessarily reflect those of the National Institute of Child Health and Human Development. Oral contraceptive and placebo pills were provided by Wyeth Pharmaceuticals, Collegeville, PA. Additional work on the study was performed by Nancy Gallagher, R.N.",

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Challenges of Conducting a Placebo-Controlled Trial for Dysmenorrhea in Adolescents

Abstract

Keywords

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