TY - JOUR
T1 - CEST theranostics
T2 - Label-free MR imaging of anticancer drugs
AU - Li, Yuguo
AU - Chen, Hanwei
AU - Xu, Jiadi
AU - Yadav, Nirbhay N.
AU - Chan, Kannie W.Y.
AU - Luo, Liangping
AU - McMahon, Michael T.
AU - Vogelstein, Bert
AU - Van Zijl, Peter C.M.
AU - Zhou, Shibin
AU - Liu, Guanshu
PY - 2016
Y1 - 2016
N2 - Image-guided drug delivery is of great clinical interest. Here, we explored a direct way, namely CEST theranostics, to detect diamagnetic anticancer drugs simply through their inherent Chemical Exchange Saturation Transfer (CEST) MRI signal, and demonstrated its application in image-guided drug delivery of nanoparticulate chemotherapeutics. We first screened 22 chemotherapeutic agents and characterized the CEST properties of representative agents and natural analogs in three major categories, i.e., pyrimidine analogs, purine analogs, and antifolates, with respect to chemical structures. Utilizing the inherent CEST MRI signal of gemcitabine, a widely used anticancer drug, the tumor uptake of the i.v.-injected, drug-loaded liposomes was successfully detected in CT26 mouse tumors. Such label-free CEST MRI theranostics provides a new imaging means, potentially with an immediate clinical impact, to monitor the drug delivery in cancer.
AB - Image-guided drug delivery is of great clinical interest. Here, we explored a direct way, namely CEST theranostics, to detect diamagnetic anticancer drugs simply through their inherent Chemical Exchange Saturation Transfer (CEST) MRI signal, and demonstrated its application in image-guided drug delivery of nanoparticulate chemotherapeutics. We first screened 22 chemotherapeutic agents and characterized the CEST properties of representative agents and natural analogs in three major categories, i.e., pyrimidine analogs, purine analogs, and antifolates, with respect to chemical structures. Utilizing the inherent CEST MRI signal of gemcitabine, a widely used anticancer drug, the tumor uptake of the i.v.-injected, drug-loaded liposomes was successfully detected in CT26 mouse tumors. Such label-free CEST MRI theranostics provides a new imaging means, potentially with an immediate clinical impact, to monitor the drug delivery in cancer.
KW - CEST
KW - Chemotherapy
KW - Image-guided drug delivery
KW - MRI
KW - Theranostics
UR - http://www.scopus.com/inward/record.url?scp=84981161238&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84981161238&partnerID=8YFLogxK
U2 - 10.18632/oncotarget.7141
DO - 10.18632/oncotarget.7141
M3 - Article
C2 - 26837220
AN - SCOPUS:84981161238
SN - 1949-2553
VL - 7
SP - 6369
EP - 6378
JO - Oncotarget
JF - Oncotarget
IS - 6
ER -