TY - JOUR
T1 - Cerebrovascular reactivity MRI as a biomarker for cerebral small vessel disease–related cognitive decline
T2 - Multi-site validation in the MarkVCID Consortium
AU - Liu, Peiying
AU - Lin, Zixuan
AU - Hazel, Kaisha
AU - Pottanat, George
AU - Xu, Cuimei
AU - Jiang, Dengrong
AU - Pillai, Jay J.
AU - Lucke, Emma
AU - Bauer, Christopher E.
AU - Gold, Brian T.
AU - Greenberg, Steven M.
AU - Helmer, Karl G.
AU - Jann, Kay
AU - Jicha, Gregory
AU - Kramer, Joel
AU - Maillard, Pauline
AU - Mulavelil, Rachel M.
AU - Rodriguez, Pavel
AU - Satizabal, Claudia L.
AU - Schwab, Kristin
AU - Seshadri, Sudha
AU - Singh, Herpreet
AU - Velarde Dediós, Ángel G.
AU - Wang, Danny J.J.
AU - Kalyani, Rita R.
AU - Moghekar, Abhay
AU - Rosenberg, Paul B.
AU - Yasar, Sevil
AU - Albert, Marilyn
AU - Lu, Hanzhang
N1 - Publisher Copyright:
© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2024/8
Y1 - 2024/8
N2 - INTRODUCTION: Vascular contributions to cognitive impairment and dementia (VCID) represent a major factor in cognitive decline in older adults. The present study examined the relationship between cerebrovascular reactivity (CVR) measured by magnetic resonance imaging (MRI) and cognitive function in a multi-site study, using a predefined hypothesis. METHODS: We conducted the study in a total of three analysis sites and 263 subjects. Each site performed an identical CVR MRI procedure using 5% carbon dioxide inhalation. A global cognitive measure of Montreal Cognitive Assessment (MoCA) and an executive function measure of item response theory (IRT) score were used as outcomes. RESULTS: CVR and MoCA were positively associated, and this relationship was reproduced at all analysis sites. CVR was found to be positively associated with executive function. DISCUSSION: The predefined hypothesis on the association between CVR and a global cognitive score was validated in three independent analysis sites, providing support for CVR as a biomarker in VCID. Highlights: This study measured a novel functional index of small arteries referred to as cerebrovascular reactivity (CVR). CVR was positively associated with global cognition in older adults. This finding was observed in three independent cohorts at three sites. Our statistical analysis plan was predefined before beginning data collection.
AB - INTRODUCTION: Vascular contributions to cognitive impairment and dementia (VCID) represent a major factor in cognitive decline in older adults. The present study examined the relationship between cerebrovascular reactivity (CVR) measured by magnetic resonance imaging (MRI) and cognitive function in a multi-site study, using a predefined hypothesis. METHODS: We conducted the study in a total of three analysis sites and 263 subjects. Each site performed an identical CVR MRI procedure using 5% carbon dioxide inhalation. A global cognitive measure of Montreal Cognitive Assessment (MoCA) and an executive function measure of item response theory (IRT) score were used as outcomes. RESULTS: CVR and MoCA were positively associated, and this relationship was reproduced at all analysis sites. CVR was found to be positively associated with executive function. DISCUSSION: The predefined hypothesis on the association between CVR and a global cognitive score was validated in three independent analysis sites, providing support for CVR as a biomarker in VCID. Highlights: This study measured a novel functional index of small arteries referred to as cerebrovascular reactivity (CVR). CVR was positively associated with global cognition in older adults. This finding was observed in three independent cohorts at three sites. Our statistical analysis plan was predefined before beginning data collection.
KW - Montreal Cognitive Assessment
KW - blood oxygenation level dependent
KW - carbon dioxide
KW - cerebrovascular reactivity
KW - cognitive function
KW - magnetic resonance imaging
KW - vascular cognitive impairment
KW - vascular cognitive impairment and dementia
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U2 - 10.1002/alz.13888
DO - 10.1002/alz.13888
M3 - Article
C2 - 38951718
AN - SCOPUS:85197576906
SN - 1552-5260
VL - 20
SP - 5281
EP - 5289
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 8
ER -