Cerebrovascular alterations in Alzheimer disease incidental or pathogenic?

Costantino Iadecola; Rebecca F. Gottesman

doi:10.1161/CIRCRESAHA.118.313400

Cerebrovascular alterations in Alzheimer disease incidental or pathogenic?

Costantino Iadecola, Rebecca F. Gottesman

School of Medicine

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Alzheimer disease (AD)-the leading cause of cognitive impairment in the elderly-has traditionally been considered a disease of neurons. Structural and functional alterations of cerebral blood vessels also occur, but direct evidence of a causal involvement in the pathobiology of the disease has been lacking. This viewpoint will review new data that may help shed light into the intriguing association between vascular and neurodegenerative pathology.

Original language	English (US)
Pages (from-to)	406-408
Number of pages	3
Journal	Circulation research
Volume	123
Issue number	4
DOIs	https://doi.org/10.1161/CIRCRESAHA.118.313400
State	Published - 2018

Keywords

Alzheimer disease
Blood-brain barrier
Dementia
Neurons
Risk factors

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

Access to Document

10.1161/CIRCRESAHA.118.313400

Cite this

@article{4bc47e9ec3854098bbad2af86a55eef5,

title = "Cerebrovascular alterations in Alzheimer disease incidental or pathogenic?",

abstract = "Alzheimer disease (AD)-the leading cause of cognitive impairment in the elderly-has traditionally been considered a disease of neurons. Structural and functional alterations of cerebral blood vessels also occur, but direct evidence of a causal involvement in the pathobiology of the disease has been lacking. This viewpoint will review new data that may help shed light into the intriguing association between vascular and neurodegenerative pathology.",

keywords = "Alzheimer disease, Blood-brain barrier, Dementia, Neurons, Risk factors",

author = "Costantino Iadecola and Gottesman, {Rebecca F.}",

note = "Funding Information: Supported by National Institutes of Health grants R37-NS089323 (Dr Iadecola), R01-NS100447 (Dr Iadecola), R01-NS09544 (Dr Iadecola), R01-NS/HL037853 (Dr Iadecola), K24-AG052573 (R.F. Gottesman), RF1-AG050745 (R.F. Gottesman), and R01-AG040282 (R.F. Gottesman). Funding Information: Supported by National Institutes of Health grants R37-NS089323 (Dr Iadecola), R01-NS100447 (Dr Iadecola), R01-NS09544 (Dr Iadecola), R01-NS/HL037853 (Dr Iadecola), K24-AG052573 (R.F. Gottesman), RF1-AG050745 (R.F. Gottesman), and R01-AG040282 (R.F. Gottesman).*%blankline%* Publisher Copyright: {\textcopyright} 2018 American Heart Association, Inc.",

year = "2018",

doi = "10.1161/CIRCRESAHA.118.313400",

language = "English (US)",

volume = "123",

pages = "406--408",

journal = "Circulation research",

issn = "0009-7330",