Cerebrospinal fluid neopterin in human immunodeficiency virus type 1 infection

Bruce J. Brew, Ravi B. Bhalla, Morris Paul, H. Gallardo, Justin C. McArthur, Morton K. Schwartz, Richard W. Price

Research output: Contribution to journalArticlepeer-review

140 Scopus citations


We evaluated cerebrospinal fluid (CSF) concentrations of neopterin, a putative marker of activated macrophages, in 97 subjects infected with human immunodeficiency virus type 1 who had a spectrum of neurological complications. The highest CSF neopterin concentrations occurred in those with neurological opportunistic infections, primary central nervous systems lymphoma, and acquired immunodeficiency syndrome (AIDS) dementia complex. In general, the CSF concentration of neopterin was independent of CSF cell count and blood‐brain barrier disruption to albumin. In the patients with AIDS dementia complex, CSF neopterin concentrations correlated with severity of disease and decreased in conjunction with clinical improvement following treatment with zidovudine. These results suggest that CSF neopterin, although not disease‐specific, may be useful as a surrogate marker for the presence of AIDS dementia complex and its response to antiviral therapy.

Original languageEnglish (US)
Pages (from-to)556-560
Number of pages5
JournalAnnals of neurology
Issue number4
StatePublished - Oct 1990

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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