TY - JOUR
T1 - Cerebrospinal fluid monoamine precursor and metabolite levels in children treated for leukemia
T2 - Age and sex effects and individual variability
AU - Riddle, Mark A.
AU - Anderson, George M.
AU - McIntosh, Sue
AU - Harcherik, Diane F.
AU - Shaywitz, Bennett A.
AU - Cohen, Donald J.
N1 - Funding Information:
WM., B.A.% M.A.R., D.J.C.), ami Laboratory Medicine (G.M.A.), Yale University school of Medicine, & Yale-New Heven Medical Center. New Heven, CT. Supported in part by MIiCRC Grant MH30929, NICHD Grant HD-03008, National Research Service Award 1~32 ~~109101 (M.A.R.), and Grant ACS-IN-31-X-J from the American Cancer Society. Address mpnht m¶UeS~ to Dr. MarL A. Riddle, Child Study Center, Yale University, 230 South Frontage Road, po bob 3333, New Haven, tT 06510-8009. Received November 30. 1984; revised August 8, 1985.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1986/1
Y1 - 1986/1
N2 - Lumbar cerebrospinal fluid (CSF) was obtained from children during and following treatment for acute lymphoblastic leukemia (ALL). One hundred ninety-two CSF samples from 50 subjects, which were selected to minimize the effects of the disease and its treatment (i.e., to approach "normality" as closely as possible), were analyzed for the monoamine precursors tyrosine (Tyr) and tryptophan (Trp) and the metabolites homo- vanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA). Levels of HVA (p < 0.0001), 5-HIAA (p < 0.002), and Tyr (p < 0.05) decreased with age from 3 to 17 years. Sig- nificant correlations were observed between the acid metabolites HVA and 5-HIAA (r = 0.79) and between the amino acid precursors Tyr and Trp (r = 0.71). Within individuals, levels of all four compounds were relatively stable over time, with total mean coefficient of variation ranging from 20% to 25%. No significant sex differences for CSF levels of HVA, 5-HIAA, Tyr, or Trp were found. Assessment of CSF monoamine precursors and metabolites in children treated for ALL may provide a method for understanding the chronic effect of CNS trauma on the ontogeny of monoamine systems.
AB - Lumbar cerebrospinal fluid (CSF) was obtained from children during and following treatment for acute lymphoblastic leukemia (ALL). One hundred ninety-two CSF samples from 50 subjects, which were selected to minimize the effects of the disease and its treatment (i.e., to approach "normality" as closely as possible), were analyzed for the monoamine precursors tyrosine (Tyr) and tryptophan (Trp) and the metabolites homo- vanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA). Levels of HVA (p < 0.0001), 5-HIAA (p < 0.002), and Tyr (p < 0.05) decreased with age from 3 to 17 years. Sig- nificant correlations were observed between the acid metabolites HVA and 5-HIAA (r = 0.79) and between the amino acid precursors Tyr and Trp (r = 0.71). Within individuals, levels of all four compounds were relatively stable over time, with total mean coefficient of variation ranging from 20% to 25%. No significant sex differences for CSF levels of HVA, 5-HIAA, Tyr, or Trp were found. Assessment of CSF monoamine precursors and metabolites in children treated for ALL may provide a method for understanding the chronic effect of CNS trauma on the ontogeny of monoamine systems.
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U2 - 10.1016/0006-3223(86)90009-0
DO - 10.1016/0006-3223(86)90009-0
M3 - Article
C2 - 2417634
AN - SCOPUS:0022912480
SN - 0006-3223
VL - 21
SP - 69
EP - 83
JO - Biological psychiatry
JF - Biological psychiatry
IS - 1
ER -