Cerebrospinal fluid monoamine metabolites in patients with infantile spasms

Faye Silverstein, Michael V. Johnston

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


We measured CSF levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) by high-performance liquid chromatography in seven children with infantile spasms and in a group of ageand sex-matched controls. The mean concentration of the serotonin metabolite 5-HIAA was 40% (p < 0.01) lower in the infantile spasms group as compared with controls; HVA levels were similar in both groups. The data provide additional evidence that serotonin metabolism is abnormal in patients with infantile spasms.

Original languageEnglish (US)
Pages (from-to)102-105
Number of pages4
Issue number1
StatePublished - Jan 1984
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Cerebrospinal fluid monoamine metabolites in patients with infantile spasms'. Together they form a unique fingerprint.

Cite this