CEREBROSPINAL-FLUID LYMPHOCYTE POPULATIONS AND IMMUNE COMPLEXES IN ACTIVE MULTIPLE SCLEROSIS

P. K. Coyle; Robert L. Hirsch; Patricia O'Donnell; Benjamin R. Brooks; Steven R. Cohen; Richard T. Johnson; Jerry S. Wolinsky

doi:10.1016/S0140-6736(80)90121-X

CEREBROSPINAL-FLUID LYMPHOCYTE POPULATIONS AND IMMUNE COMPLEXES IN ACTIVE MULTIPLE SCLEROSIS

P. K. Coyle, Robert L. Hirsch, Patricia O'Donnell, Benjamin R. Brooks, Steven R. Cohen, Richard T. Johnson, Jerry S. Wolinsky

School of Medicine

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

A specific subpopulation of mononuclear cells bearing a surface receptor for the Fc portion of IgG was considerably reduced in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients during exacerbation, but returned toward normal levels as the patient entered remission. Low concentrations of immune complexes were found in the CSF in nearly 50% of MS patients during exacerbations but immune complexes were not found in patients with stable MS.

Original language	English (US)
Pages (from-to)	229-232
Number of pages	4
Journal	The Lancet
Volume	316
Issue number	8188
DOIs	https://doi.org/10.1016/S0140-6736(80)90121-X
State	Published - 1980

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(80)90121-X

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@article{c776273e61794a4d8bd1befdb1ddb126,

title = "CEREBROSPINAL-FLUID LYMPHOCYTE POPULATIONS AND IMMUNE COMPLEXES IN ACTIVE MULTIPLE SCLEROSIS",

abstract = "A specific subpopulation of mononuclear cells bearing a surface receptor for the Fc portion of IgG was considerably reduced in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients during exacerbation, but returned toward normal levels as the patient entered remission. Low concentrations of immune complexes were found in the CSF in nearly 50% of MS patients during exacerbations but immune complexes were not found in patients with stable MS.",

author = "Coyle, {P. K.} and Hirsch, {Robert L.} and Patricia O'Donnell and Brooks, {Benjamin R.} and Cohen, {Steven R.} and Johnson, {Richard T.} and Wolinsky, {Jerry S.}",

year = "1980",

doi = "10.1016/S0140-6736(80)90121-X",

language = "English (US)",

volume = "316",

pages = "229--232",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier B.V.",

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T1 - CEREBROSPINAL-FLUID LYMPHOCYTE POPULATIONS AND IMMUNE COMPLEXES IN ACTIVE MULTIPLE SCLEROSIS

AU - Coyle, P. K.

AU - Hirsch, Robert L.

AU - O'Donnell, Patricia

AU - Brooks, Benjamin R.

AU - Cohen, Steven R.

AU - Johnson, Richard T.

AU - Wolinsky, Jerry S.

PY - 1980

Y1 - 1980

N2 - A specific subpopulation of mononuclear cells bearing a surface receptor for the Fc portion of IgG was considerably reduced in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients during exacerbation, but returned toward normal levels as the patient entered remission. Low concentrations of immune complexes were found in the CSF in nearly 50% of MS patients during exacerbations but immune complexes were not found in patients with stable MS.

AB - A specific subpopulation of mononuclear cells bearing a surface receptor for the Fc portion of IgG was considerably reduced in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients during exacerbation, but returned toward normal levels as the patient entered remission. Low concentrations of immune complexes were found in the CSF in nearly 50% of MS patients during exacerbations but immune complexes were not found in patients with stable MS.

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U2 - 10.1016/S0140-6736(80)90121-X

DO - 10.1016/S0140-6736(80)90121-X

M3 - Article

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AN - SCOPUS:0018870825

SN - 0140-6736

VL - 316

SP - 229

EP - 232

JO - The Lancet

JF - The Lancet

IS - 8188

ER -

CEREBROSPINAL-FLUID LYMPHOCYTE POPULATIONS AND IMMUNE COMPLEXES IN ACTIVE MULTIPLE SCLEROSIS

Abstract

ASJC Scopus subject areas

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