TY - JOUR
T1 - Cerebrospinal fluid biogenic amines in obsessive compulsive disorder, tourette’s syndrome, and healthy controls
AU - Leckman, James F.
AU - Goodman, Wayne K.
AU - Anderson, George M.
AU - Riddle, Mark A.
AU - Chappell, Phillip B.
AU - McSwiggan-Hardin, Maureen T.
AU - McDougle, Christopher J.
AU - Scahill, Lawrence D.
AU - Ort, Sharon I.
AU - Pauls, David L.
AU - Cohen, Donald J.
AU - Price, Lawrence H.
N1 - Funding Information:
This work was supported by NIH grants MH44843, MH49351, MH00508, NS16648, HD03008, RR00125, and RR06022 (General ClinicalR esearch Centers), MH30929 (Mental Health Clinical Research Center), and the Tourette Syndrome Association. The authors would also like to thank Katrina Artavanis, Taraneh Shafti, and Colin Bondi for their help with the completion of this study and Drs Ann M. Rasmusson, Matthew J. During, Paul J. Lombroso, Robert A. Makuch, Bradley S. Peterson, and Yanki Yazgan for their comments on an earlier draft of this report.
PY - 1995/2
Y1 - 1995/2
N2 - To examine the role of noradrenergic, dopaminergic, and serotonergic mechanisms in the pathobiology of obsessive compulsive disorder (OCD) and Tourette's syndrome (TS), concentrations of tyrosine (TYR), norepinephrine (NE), 3-methoxy-4-hydroxyphenylethylene glycol (MHPG), homovanillic acid (HVA), tryptophan (TRP), and 5-hydroxyindoleacetic acid (5-HIAA) were measured in the lumbar cerebrospinal fluid (CSF) of 39 medication- free OCD patients, 33 medication-free TS patients, and 44 healthy volunteers. CSF TYR concentrations were reduced (p <.05) in the OCD patients compared to the healthy subjects. CSF NE in TS patients was 55% higher than in healthy controls (p <. 001) and 35% higher than in OCD patients (p <.001). After covarying for height, CSF FTVA levels were reduced (p <.05) in the OCD group compared to TS patients but not compared to the normal volunteers. No mean differences in CSF MHPG, TRP, and 5-HIAA were observed in this study across the three groups. The CSF NE data support the hypothesis that noradrenergic mechanisms are involved in the pathobiology of TS. Alterations in the balance of noradrenergic, dopaminergic, and serotonergic systems are likely involved in the pathobiology of OCD.
AB - To examine the role of noradrenergic, dopaminergic, and serotonergic mechanisms in the pathobiology of obsessive compulsive disorder (OCD) and Tourette's syndrome (TS), concentrations of tyrosine (TYR), norepinephrine (NE), 3-methoxy-4-hydroxyphenylethylene glycol (MHPG), homovanillic acid (HVA), tryptophan (TRP), and 5-hydroxyindoleacetic acid (5-HIAA) were measured in the lumbar cerebrospinal fluid (CSF) of 39 medication- free OCD patients, 33 medication-free TS patients, and 44 healthy volunteers. CSF TYR concentrations were reduced (p <.05) in the OCD patients compared to the healthy subjects. CSF NE in TS patients was 55% higher than in healthy controls (p <. 001) and 35% higher than in OCD patients (p <.001). After covarying for height, CSF FTVA levels were reduced (p <.05) in the OCD group compared to TS patients but not compared to the normal volunteers. No mean differences in CSF MHPG, TRP, and 5-HIAA were observed in this study across the three groups. The CSF NE data support the hypothesis that noradrenergic mechanisms are involved in the pathobiology of TS. Alterations in the balance of noradrenergic, dopaminergic, and serotonergic systems are likely involved in the pathobiology of OCD.
KW - 3-methoxy-4- hydroxyphenylethylene glycol
KW - 5-hydroxyindoleacetic acid
KW - CSF
KW - Homovanillic acid
KW - Norepinephrine
KW - Obsessive compulsive disorder
KW - Tourette's syndrome
KW - Tryptophan
KW - Tyrosine
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U2 - 10.1038/sj.npp.1380241
DO - 10.1038/sj.npp.1380241
M3 - Article
C2 - 7766289
AN - SCOPUS:84970060564
SN - 0893-133X
VL - 12
SP - 73
EP - 86
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
IS - 1
ER -