TY - JOUR
T1 - Cerebrospinal fluid and behavioral changes after methyltestosterone administration
T2 - Preliminary findings
AU - Daly, R. C.
AU - Su, T. P.
AU - Schmidt, P. J.
AU - Pickar, D.
AU - Murphy, D. L.
AU - Rubinow, D. R.
PY - 2001
Y1 - 2001
N2 - Background: Anabolic androgen steroid abuse is associated with multiple psychiatric symptoms and is a significant public health problem. The biological mechanisms underlying behavioral symptom development are poorly understood. Subjects and Methods: We examined levels of monoamine metabolites, neurohormones, and neuropeptides in the cerebrospinal fluid (CSF) of 17 healthy men, at baseline and following 6 days of methyltestosterone (MT) administration (3 days of 40 mg/d, then 3 days of 240 mg/d). Subjects received MT or placebo in a fixed sequence, with neither subjects nor raters aware of the order. Potential relationships were examined between CSF measures, CSF MT levels, and behavioral changes measured on a visual analog scale. Results: Following MT administration, levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) were significantly lower (mean±SD, 103.8±47 vs 122.0±50.7 pmol/mL; P
AB - Background: Anabolic androgen steroid abuse is associated with multiple psychiatric symptoms and is a significant public health problem. The biological mechanisms underlying behavioral symptom development are poorly understood. Subjects and Methods: We examined levels of monoamine metabolites, neurohormones, and neuropeptides in the cerebrospinal fluid (CSF) of 17 healthy men, at baseline and following 6 days of methyltestosterone (MT) administration (3 days of 40 mg/d, then 3 days of 240 mg/d). Subjects received MT or placebo in a fixed sequence, with neither subjects nor raters aware of the order. Potential relationships were examined between CSF measures, CSF MT levels, and behavioral changes measured on a visual analog scale. Results: Following MT administration, levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) were significantly lower (mean±SD, 103.8±47 vs 122.0±50.7 pmol/mL; P
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M3 - Article
C2 - 11177119
AN - SCOPUS:0035133020
SN - 0003-990X
VL - 58
SP - 172
EP - 177
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 2
ER -