Cerebrospinal fluid and behavioral changes after methyltestosterone administration: Preliminary findings

R. C. Daly, T. P. Su, P. J. Schmidt, D. Pickar, D. L. Murphy, D. R. Rubinow

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


Background: Anabolic androgen steroid abuse is associated with multiple psychiatric symptoms and is a significant public health problem. The biological mechanisms underlying behavioral symptom development are poorly understood. Subjects and Methods: We examined levels of monoamine metabolites, neurohormones, and neuropeptides in the cerebrospinal fluid (CSF) of 17 healthy men, at baseline and following 6 days of methyltestosterone (MT) administration (3 days of 40 mg/d, then 3 days of 240 mg/d). Subjects received MT or placebo in a fixed sequence, with neither subjects nor raters aware of the order. Potential relationships were examined between CSF measures, CSF MT levels, and behavioral changes measured on a visual analog scale. Results: Following MT administration, levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) were significantly lower (mean±SD, 103.8±47 vs 122.0±50.7 pmol/mL; P

Original languageEnglish (US)
Pages (from-to)172-177
Number of pages6
JournalArchives of General Psychiatry
Issue number2
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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