Cerebrospinal fluid and behavioral changes after methyltestosterone administration: Preliminary findings

R. C. Daly; T. P. Su; P. J. Schmidt; D. Pickar; D. L. Murphy; D. R. Rubinow

Cerebrospinal fluid and behavioral changes after methyltestosterone administration: Preliminary findings

R. C. Daly, T. P. Su, P. J. Schmidt, D. Pickar, D. L. Murphy, D. R. Rubinow

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Anabolic androgen steroid abuse is associated with multiple psychiatric symptoms and is a significant public health problem. The biological mechanisms underlying behavioral symptom development are poorly understood. Subjects and Methods: We examined levels of monoamine metabolites, neurohormones, and neuropeptides in the cerebrospinal fluid (CSF) of 17 healthy men, at baseline and following 6 days of methyltestosterone (MT) administration (3 days of 40 mg/d, then 3 days of 240 mg/d). Subjects received MT or placebo in a fixed sequence, with neither subjects nor raters aware of the order. Potential relationships were examined between CSF measures, CSF MT levels, and behavioral changes measured on a visual analog scale. Results: Following MT administration, levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) were significantly lower (mean±SD, 103.8±47 vs 122.0±50.7 pmol/mL; P

Original language	English (US)
Pages (from-to)	172-177
Number of pages	6
Journal	Archives of General Psychiatry
Volume	58
Issue number	2
State	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Psychiatry and Mental health

Cite this

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title = "Cerebrospinal fluid and behavioral changes after methyltestosterone administration: Preliminary findings",

abstract = "Background: Anabolic androgen steroid abuse is associated with multiple psychiatric symptoms and is a significant public health problem. The biological mechanisms underlying behavioral symptom development are poorly understood. Subjects and Methods: We examined levels of monoamine metabolites, neurohormones, and neuropeptides in the cerebrospinal fluid (CSF) of 17 healthy men, at baseline and following 6 days of methyltestosterone (MT) administration (3 days of 40 mg/d, then 3 days of 240 mg/d). Subjects received MT or placebo in a fixed sequence, with neither subjects nor raters aware of the order. Potential relationships were examined between CSF measures, CSF MT levels, and behavioral changes measured on a visual analog scale. Results: Following MT administration, levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) were significantly lower (mean±SD, 103.8±47 vs 122.0±50.7 pmol/mL; P",

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language = "English (US)",

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T1 - Cerebrospinal fluid and behavioral changes after methyltestosterone administration

T2 - Preliminary findings

AU - Daly, R. C.

AU - Su, T. P.

AU - Schmidt, P. J.

AU - Pickar, D.

AU - Murphy, D. L.

AU - Rubinow, D. R.

PY - 2001

Y1 - 2001

N2 - Background: Anabolic androgen steroid abuse is associated with multiple psychiatric symptoms and is a significant public health problem. The biological mechanisms underlying behavioral symptom development are poorly understood. Subjects and Methods: We examined levels of monoamine metabolites, neurohormones, and neuropeptides in the cerebrospinal fluid (CSF) of 17 healthy men, at baseline and following 6 days of methyltestosterone (MT) administration (3 days of 40 mg/d, then 3 days of 240 mg/d). Subjects received MT or placebo in a fixed sequence, with neither subjects nor raters aware of the order. Potential relationships were examined between CSF measures, CSF MT levels, and behavioral changes measured on a visual analog scale. Results: Following MT administration, levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) were significantly lower (mean±SD, 103.8±47 vs 122.0±50.7 pmol/mL; P

AB - Background: Anabolic androgen steroid abuse is associated with multiple psychiatric symptoms and is a significant public health problem. The biological mechanisms underlying behavioral symptom development are poorly understood. Subjects and Methods: We examined levels of monoamine metabolites, neurohormones, and neuropeptides in the cerebrospinal fluid (CSF) of 17 healthy men, at baseline and following 6 days of methyltestosterone (MT) administration (3 days of 40 mg/d, then 3 days of 240 mg/d). Subjects received MT or placebo in a fixed sequence, with neither subjects nor raters aware of the order. Potential relationships were examined between CSF measures, CSF MT levels, and behavioral changes measured on a visual analog scale. Results: Following MT administration, levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) were significantly lower (mean±SD, 103.8±47 vs 122.0±50.7 pmol/mL; P

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Cerebrospinal fluid and behavioral changes after methyltestosterone administration: Preliminary findings

Abstract

ASJC Scopus subject areas

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