Cerebral white matter disease in late-onset paranoid psychosis

John C.S. Breitner, Mustafa M. Husain, Gary S. Figiel, K. Ranga R. Krishman, Orest B. Boyko

Research output: Contribution to journalArticlepeer-review

86 Scopus citations


We examined magnetic resonance (MR) scans of the heads of 8 patients with late onset psychosis and 8 aged controls. Although some patients had mild cognitive impairment, none had depression or a history or examination suggesting focal brain disease. Thus, all patients met DSM-III-R criteria for late-onset schizophrenia All 8 patients showed significant leukoencephalopathy or vascular pathology on MR imaging, and temporoparietal and occipital lesions were especially prominent. Little such pathology was evident on control scans. We suggest that focal brain disease of vascular origin may be associated with late-onset psychosis, and that MR scanning of such cases may provide important clues to pathologenesis.

Original languageEnglish (US)
Pages (from-to)266-274
Number of pages9
JournalBiological psychiatry
Issue number3
StatePublished - Aug 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Biological Psychiatry


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