Cerebral ventricular size and cerebrospinal fluid acetylcholinesterase levels in senile dementia of the Alzheimer type

Godfrey D. Pearlson; Larry E. Tune

doi:10.1016/0165-1781(86)90038-7

Cerebral ventricular size and cerebrospinal fluid acetylcholinesterase levels in senile dementia of the Alzheimer type

Godfrey D. Pearlson, Larry E. Tune

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Computed tomography (CT) was performed in 16 patients with a diagnosis of senile dementia of the Alzheimer type (SDAT). CT scans were rated without knowledge of clinical and laboratory data, and lateral ventricle-brain ratios (VBRs) calculated. Cerebrospinal fluid (CSF) acetylcholinesterase (AChE) activity was measured by radioenzymatic assay in all patients, and degree of dementia quantified using the Mini-Mental State Examination (MMSE). There were significant correlations between cerebral atrophy as assessed by VBR and CSF AChE activity. Cognitive impairment on MMSE also correlated significantly with VBR. These correlations were not accounted for by age, dilutional effects, or duration of illness. The relationship between VBR and AChE activity demonstrates an association between two independently determined pre-mortem measures of illness.

Original language	English (US)
Pages (from-to)	23-29
Number of pages	7
Journal	Psychiatry research
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(86)90038-7
State	Published - Jan 1986
Externally published	Yes

Keywords

Alzheimer's disease
acetylcholinesterase
cerebrospinal fluid
computed tomography
dementia
ventricle-to-brain ratio

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0165-1781(86)90038-7

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title = "Cerebral ventricular size and cerebrospinal fluid acetylcholinesterase levels in senile dementia of the Alzheimer type",

abstract = "Computed tomography (CT) was performed in 16 patients with a diagnosis of senile dementia of the Alzheimer type (SDAT). CT scans were rated without knowledge of clinical and laboratory data, and lateral ventricle-brain ratios (VBRs) calculated. Cerebrospinal fluid (CSF) acetylcholinesterase (AChE) activity was measured by radioenzymatic assay in all patients, and degree of dementia quantified using the Mini-Mental State Examination (MMSE). There were significant correlations between cerebral atrophy as assessed by VBR and CSF AChE activity. Cognitive impairment on MMSE also correlated significantly with VBR. These correlations were not accounted for by age, dilutional effects, or duration of illness. The relationship between VBR and AChE activity demonstrates an association between two independently determined pre-mortem measures of illness.",

keywords = "Alzheimer's disease, acetylcholinesterase, cerebrospinal fluid, computed tomography, dementia, ventricle-to-brain ratio",

author = "Pearlson, {Godfrey D.} and Tune, {Larry E.}",

note = "Funding Information: Acknowledgments. The research reported was supported by grants from the Oscar and Lillian Stempler Foundation, the Eleanor and T. Rowe Price Foundation, The Johns Hopkins Outpatient Department Clinical Research Center (NIH #RR00722,N IH Division of Resource Research). and the Barnes Fund. The authors thank Paul J. Moberg, M.A., for assistancew ith data analysis and graphics, and Ms. Donna A. Wheatley for secretarial assistance.",

year = "1986",

month = jan,

doi = "10.1016/0165-1781(86)90038-7",

language = "English (US)",

volume = "17",

pages = "23--29",

journal = "Psychiatry research",

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publisher = "Elsevier Ireland Ltd",

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T1 - Cerebral ventricular size and cerebrospinal fluid acetylcholinesterase levels in senile dementia of the Alzheimer type

AU - Pearlson, Godfrey D.

AU - Tune, Larry E.

N1 - Funding Information: Acknowledgments. The research reported was supported by grants from the Oscar and Lillian Stempler Foundation, the Eleanor and T. Rowe Price Foundation, The Johns Hopkins Outpatient Department Clinical Research Center (NIH #RR00722,N IH Division of Resource Research). and the Barnes Fund. The authors thank Paul J. Moberg, M.A., for assistancew ith data analysis and graphics, and Ms. Donna A. Wheatley for secretarial assistance.

PY - 1986/1

Y1 - 1986/1

N2 - Computed tomography (CT) was performed in 16 patients with a diagnosis of senile dementia of the Alzheimer type (SDAT). CT scans were rated without knowledge of clinical and laboratory data, and lateral ventricle-brain ratios (VBRs) calculated. Cerebrospinal fluid (CSF) acetylcholinesterase (AChE) activity was measured by radioenzymatic assay in all patients, and degree of dementia quantified using the Mini-Mental State Examination (MMSE). There were significant correlations between cerebral atrophy as assessed by VBR and CSF AChE activity. Cognitive impairment on MMSE also correlated significantly with VBR. These correlations were not accounted for by age, dilutional effects, or duration of illness. The relationship between VBR and AChE activity demonstrates an association between two independently determined pre-mortem measures of illness.

AB - Computed tomography (CT) was performed in 16 patients with a diagnosis of senile dementia of the Alzheimer type (SDAT). CT scans were rated without knowledge of clinical and laboratory data, and lateral ventricle-brain ratios (VBRs) calculated. Cerebrospinal fluid (CSF) acetylcholinesterase (AChE) activity was measured by radioenzymatic assay in all patients, and degree of dementia quantified using the Mini-Mental State Examination (MMSE). There were significant correlations between cerebral atrophy as assessed by VBR and CSF AChE activity. Cognitive impairment on MMSE also correlated significantly with VBR. These correlations were not accounted for by age, dilutional effects, or duration of illness. The relationship between VBR and AChE activity demonstrates an association between two independently determined pre-mortem measures of illness.

KW - Alzheimer's disease

KW - acetylcholinesterase

KW - cerebrospinal fluid

KW - computed tomography

KW - dementia

KW - ventricle-to-brain ratio

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ER -

Cerebral ventricular size and cerebrospinal fluid acetylcholinesterase levels in senile dementia of the Alzheimer type

Abstract

Keywords

ASJC Scopus subject areas

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