TY - JOUR
T1 - Cerebral Ventricular Enlargement in Chronic Schizophrenia
T2 - An Association with Poor Response to Treatment
AU - Weinberger, Daniel R.
AU - Bigelow, Llewellyn B.
AU - Kleinman, Joel E.
AU - Klein, Susan T.
AU - Rosenblatt, Jack E.
AU - Wyatt, Richard Jed
PY - 1980/1
Y1 - 1980/1
N2 - Response to neuroleptic drug treatment in ten chronic schizophrenic patients with enlarged cerebral ventricles was compared with ten similar patients with normal ventricles. The groups were closely matched for age, age at onset of illness, years of illness and hospitalization, drug dosage, and plasma neuroleptic concentration as measured by radioreceptor assay. Response was significantly worse in the patients with enlarged ventricles. This finding supports the notion that ventricular enlargement is clinically relevant in patients with chronic schizophrenia and that patients with this abnormality may have a biologically different illness than similar patients without it.
AB - Response to neuroleptic drug treatment in ten chronic schizophrenic patients with enlarged cerebral ventricles was compared with ten similar patients with normal ventricles. The groups were closely matched for age, age at onset of illness, years of illness and hospitalization, drug dosage, and plasma neuroleptic concentration as measured by radioreceptor assay. Response was significantly worse in the patients with enlarged ventricles. This finding supports the notion that ventricular enlargement is clinically relevant in patients with chronic schizophrenia and that patients with this abnormality may have a biologically different illness than similar patients without it.
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U2 - 10.1001/archpsyc.1980.01780140013001
DO - 10.1001/archpsyc.1980.01780140013001
M3 - Article
C2 - 6101534
AN - SCOPUS:0018842984
SN - 0003-990X
VL - 37
SP - 11
EP - 13
JO - Archives of general psychiatry
JF - Archives of general psychiatry
IS - 1
ER -