Cerebral Sinovenous Thrombosis in Infants and Children: A Practical Approach to Management

Noa Mandel-Shorer; Christine A. Sabapathy; Pradeep Krishnan; Mukta Sharma; Neil A. Goldenberg; Leonardo R. Brandão; Mahendranath D. Moharir

doi:10.1016/j.spen.2022.100993

Cerebral Sinovenous Thrombosis in Infants and Children: A Practical Approach to Management

Noa Mandel-Shorer
, Christine A. Sabapathy
, Pradeep Krishnan
, Mukta Sharma
, Neil A. Goldenberg
, Leonardo R. Brandão
, Mahendranath D. Moharir

All Children's Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

Cerebral sinovenous thrombosis (CSVT) is a rare, yet potentially devastating disorder, associated with acute complications and long-term neurologic sequelae. Consensus-based international pediatric CSVT treatment guidelines emphasize early clinical-radiologic recognition and prompt consideration for anticoagulation therapy. However, lack of clinical trials has precluded evidence-based patient selection, anticoagulant choice, optimal monitoring parameters and treatment duration. Consequently, uncertainties and controversies persist regarding anticoagulation practices in pediatric CSVT. This review focuses on commonly encountered issues that continue to pose questions and raise debates regarding anticoagulation therapy among pediatric neurologists and hematologists.

Original language	English (US)
Article number	100993
Journal	Seminars in Pediatric Neurology
Volume	44
DOIs	https://doi.org/10.1016/j.spen.2022.100993
State	Published - Dec 2022

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

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title = "Cerebral Sinovenous Thrombosis in Infants and Children: A Practical Approach to Management",

abstract = "Cerebral sinovenous thrombosis (CSVT) is a rare, yet potentially devastating disorder, associated with acute complications and long-term neurologic sequelae. Consensus-based international pediatric CSVT treatment guidelines emphasize early clinical-radiologic recognition and prompt consideration for anticoagulation therapy. However, lack of clinical trials has precluded evidence-based patient selection, anticoagulant choice, optimal monitoring parameters and treatment duration. Consequently, uncertainties and controversies persist regarding anticoagulation practices in pediatric CSVT. This review focuses on commonly encountered issues that continue to pose questions and raise debates regarding anticoagulation therapy among pediatric neurologists and hematologists.",

author = "Noa Mandel-Shorer and Sabapathy, \{Christine A.\} and Pradeep Krishnan and Mukta Sharma and Goldenberg, \{Neil A.\} and Brand{\~a}o, \{Leonardo R.\} and Moharir, \{Mahendranath D.\}",

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year = "2022",

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doi = "10.1016/j.spen.2022.100993",

language = "English (US)",

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T1 - Cerebral Sinovenous Thrombosis in Infants and Children

T2 - A Practical Approach to Management

AU - Mandel-Shorer, Noa

AU - Sabapathy, Christine A.

AU - Krishnan, Pradeep

AU - Sharma, Mukta

AU - Goldenberg, Neil A.

AU - Brandão, Leonardo R.

AU - Moharir, Mahendranath D.

PY - 2022/12

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N2 - Cerebral sinovenous thrombosis (CSVT) is a rare, yet potentially devastating disorder, associated with acute complications and long-term neurologic sequelae. Consensus-based international pediatric CSVT treatment guidelines emphasize early clinical-radiologic recognition and prompt consideration for anticoagulation therapy. However, lack of clinical trials has precluded evidence-based patient selection, anticoagulant choice, optimal monitoring parameters and treatment duration. Consequently, uncertainties and controversies persist regarding anticoagulation practices in pediatric CSVT. This review focuses on commonly encountered issues that continue to pose questions and raise debates regarding anticoagulation therapy among pediatric neurologists and hematologists.

AB - Cerebral sinovenous thrombosis (CSVT) is a rare, yet potentially devastating disorder, associated with acute complications and long-term neurologic sequelae. Consensus-based international pediatric CSVT treatment guidelines emphasize early clinical-radiologic recognition and prompt consideration for anticoagulation therapy. However, lack of clinical trials has precluded evidence-based patient selection, anticoagulant choice, optimal monitoring parameters and treatment duration. Consequently, uncertainties and controversies persist regarding anticoagulation practices in pediatric CSVT. This review focuses on commonly encountered issues that continue to pose questions and raise debates regarding anticoagulation therapy among pediatric neurologists and hematologists.

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DO - 10.1016/j.spen.2022.100993

M3 - Article

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AN - SCOPUS:85143170721

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VL - 44

JO - Seminars in Pediatric Neurology

JF - Seminars in Pediatric Neurology

M1 - 100993

ER -

Cerebral Sinovenous Thrombosis in Infants and Children: A Practical Approach to Management

Abstract

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