Cerebral pleomorphic liposarcoma: Clinicopathologic findings

Dora Verdugo, Lysandra Voltaggio, Andrew Hoot, Fausto J. Rodriguez

Research output: Contribution to journalArticlepeer-review


Pleomorphic liposarcoma is the rarest subtype of liposarcoma. Involvement of the central nervous system by pleomorphic liposarcoma is exceptional. We present a 62-year-old woman with an intraparenchymal mass involving the left frontoparietal lobes. Histologic examination demonstrated a mesenchymal neoplasm with a dense reticulin network and pleomorphic lipoblasts. Immunohistochemical stain for adipophilin highlighted intracytoplasmic vacuoles. MDM2 immunostain was negative. A diagnosis of pleomorphic liposarcoma was made. There was no evidence of an extracranial primary neoplasm by imaging or physical exam. Pleomorphic liposarcoma may rarely present as a solitary intracranial mass, an entity that must be entertained in the differential diagnosis of pleomorphic tumors involving the brain.

Original languageEnglish (US)
Pages (from-to)233-237
Number of pages5
JournalClinical neuropathology
Issue number5
StatePublished - Oct 2019


  • Adipophilin
  • Intracranial sarcoma
  • Intraparenchymal sarcoma
  • Pleomorphic liposarcoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology


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