Cerebral ocular Whipple's disease: A 62-year odyssey from death to diagnosis

D. L. Knox, W. R. Green, J. C. Troncoso, J. H. Yardley, J. Hsu, D. S. Zee

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


A 47-year-old white man with dementia, supranuclear ophthalmoplegia, and myoclonic ocular and facial jerks died in 1931. The case report in 1936 by Ford and Walsh diagnosed encephalitis. In 1993, we made a clinical diagnosis of Whipple's disease on the basis of the 1936 publication. We restudied the pathologic material and found, in addition to extensive encephalitis, PAS- positive material in only the eye, brain, spinal cord, and pituitary. Electron microscopy demonstrated free and intracytoplasmic microorganisms in the eye and brain. We review the history of cerebral ocular Whipple's disease and the implications from this case, which occurred before the development of antibiotics.

Original languageEnglish (US)
Pages (from-to)617-625
Number of pages9
Issue number4
StatePublished - Apr 1995

ASJC Scopus subject areas

  • Clinical Neurology


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