TY - JOUR
T1 - Cerebral ocular whipple's disease
T2 - A 62-year odyssey from death to diagnosis
AU - Knox, D. L.
AU - Green, W. R.
AU - Troncoso, J. C.
AU - Yardley, J. H.
AU - Hsu, J.
AU - Zee, D. S.
PY - 1995/4
Y1 - 1995/4
N2 - Article abstract-A 47-year-old white man with dementia, supranuclear ophthalmoplegia, and myoclonic ocular and facial jerks died in 1931. The case report in 1936 by Ford and Walsh diagnosed encephalitis. In 1993, we made a clinical diagnosis of Whipple's disease on the basis of the 1936 publication. We restudied the pathologic material and found, in addition to extensive encephalitis, PAS-positive material in only the eye, brain, spinal cord, and pituitary. Electron microscopy demonstrated free and intracytoplasmic microorganisms in the eye and brain. We review the history of cerebral ocular Whipple's disease and the implications from this case, which occurred before the development of antibiotics.
AB - Article abstract-A 47-year-old white man with dementia, supranuclear ophthalmoplegia, and myoclonic ocular and facial jerks died in 1931. The case report in 1936 by Ford and Walsh diagnosed encephalitis. In 1993, we made a clinical diagnosis of Whipple's disease on the basis of the 1936 publication. We restudied the pathologic material and found, in addition to extensive encephalitis, PAS-positive material in only the eye, brain, spinal cord, and pituitary. Electron microscopy demonstrated free and intracytoplasmic microorganisms in the eye and brain. We review the history of cerebral ocular Whipple's disease and the implications from this case, which occurred before the development of antibiotics.
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U2 - 10.1212/WNL.45.4.617
DO - 10.1212/WNL.45.4.617
M3 - Review article
C2 - 7536902
AN - SCOPUS:0028912415
SN - 0028-3878
VL - 45
SP - 617
EP - 625
JO - Neurology
JF - Neurology
IS - 4
ER -