Cerebral glucose utilization is reduced in second test session

June M. Stapleton, Michael J. Morgan, Xiang Liu, Babington C.K. Yung, Robert L. Phillips, Dean F. Wong, Elias K. Shaya, Robert F. Dannals, Edythe D. London

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Cerebral glucose utilization was higher during the first positron emission tomography (PET) session than during the second session, as assayed using the PET [18F]fluorodeoxyglucose method in male human volunteers. This difference was due largely to data from subjects with low trait anxiety, since subjects with high anxiety showed similar metabolism in both PET sessions. High anxiety subjects showed greater right/left ratios of cerebral metabolism than low-anxiety subjects, particularly during the second PET session. These findings suggest that the level of anxiety may be an important variable to consider in PET studies using multiple sessions.

Original languageEnglish (US)
Pages (from-to)704-712
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number6
StatePublished - Jun 1997


  • Anxiety
  • Cerebral metabolism
  • Glucose utilization
  • Positron emission tomography

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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