Cerebral glucose utilization in polysubstance abuse

June M. Stapleton, Michael J. Morgan, Robert L. Phillips, Dean F. Wong, Babington C.K. Yung, Elias K. Shaya, Robert F. Dannals, Xiang Liu, Roger L. Grayson, Edythe D. London

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Regional cerebral glucose metabolism in subjects with histories of polysubstance abuse was compared to that in control subjects who were drawn from the same community. The substance abuse group showed lower absolute metabolic rates for glucose in lateral occipital gyrus and higher normalized metabolic rates in temporal and frontal areas, including orbitofrontal cortex. It is suggested that some patterns of brain function associated with polysubstance abuse may represent consequences of drug exposure, or they could reflect pre-existing differences that may be relevant to the etiology and maintenance of polysubstance abuse.

Original languageEnglish (US)
Pages (from-to)21-31
Number of pages11
Issue number1
StatePublished - Aug 1995


  • Brain imaging
  • Cerebral glucose metabolism
  • Drug abuse
  • Fluorodeoxyglucose
  • Positron emission tomography
  • Substance abuse

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health


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